{"id":"W3047755466","doi":"10.1158/1538-7445.pedca19-b26","title":"Abstract B26: Prometastatic effect of ICG-001, a β-catenin/CBP dependent transcription inhibitor, in osteosarcoma","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Osteosarcoma; Wnt signaling pathway; Medicine; Cancer research; Beta-catenin; Catenin; Population; Internal medicine; Oncology; Signal transduction; Biology; Cell biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000203873,0.0007502857,0.0005980765,0.0006302014,0.0002441236,0.0003386053,0.0003109344,0.0003480862,0.003645741],"category_scores_gemma":[0.000133947,0.0002049924,0.0004158046,0.0003883984,0.0003252169,0.0001597472,0.0001452211,0.0009996702,0.0007674214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002691764,"about_ca_system_score_gemma":0.0006078337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002221341,"about_ca_topic_score_gemma":0.002417172,"domain_scores_codex":[0.9999036,0.00001498183,0.000007574501,0.00002013219,0.00002237519,0.00003124573],"domain_scores_gemma":[0.999902,0.00001268822,0.00001064857,0.000007525392,0.00001065747,0.0000565517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003191873,0.00195029,0.000522679,0.0004281983,0.00003296855,0.0002668191,0.00005451958,0.0006963821,0.9806688,0.0002235791,0.001007807,0.01095606],"study_design_scores_gemma":[0.001461874,0.02674453,0.008639322,0.0000549875,0.0001456031,0.0006382346,0.00007837459,0.002029279,0.9478229,0.00008579728,0.01226428,0.00003482731],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843872,0.009072616,0.000735869,0.0002395186,0.0001651537,0.0001501353,0.00112452,0.0001700755,0.003954908],"genre_scores_gemma":[0.985854,0.005181869,0.001224381,0.0001660628,0.00004890692,0.0001013873,0.002741549,0.0000286966,0.004653208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003645741,"threshold_uncertainty_score":0.01219624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05673298182386619,"score_gpt":0.354627002038911,"score_spread":0.2978940202150447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}