{"id":"W3047784998","doi":"10.1016/j.stem.2020.07.004","title":"Universal Stem Cells: Making the Unsafe Safe","year":2020,"lang":"en","type":"letter","venue":"Cell stem cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Induced pluripotent stem cell; Stem cell; Scopus; Biology; Transplantation; Immune system; Immunology; Cancer research; Medicine; Embryonic stem cell; MEDLINE; Cell biology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003001273,0.0008147548,0.0005863671,0.0001188779,0.0003676329,0.0001956694,0.002222978,0.001294627,0.0002048403],"category_scores_gemma":[0.000002883897,0.0006700025,0.000536101,0.0002948919,0.0002720781,0.000007307873,0.001180028,0.002322009,0.001457311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001452467,"about_ca_system_score_gemma":0.0004277565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002044949,"about_ca_topic_score_gemma":0.00000474853,"domain_scores_codex":[0.9951862,0.0006509483,0.0005769577,0.001483103,0.0009070295,0.001195799],"domain_scores_gemma":[0.9974685,0.0001329368,0.000424281,0.001615369,0.0001648907,0.0001940597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006031379,0.0000341005,0.00001126502,0.0006612361,0.00008280246,0.0007299988,0.00009360186,0.00007545503,0.1471319,0.000001556357,0.8506116,0.0005061515],"study_design_scores_gemma":[0.0004359463,0.000181937,0.000001048969,0.00004370925,0.00008231802,0.00001412693,0.0002373473,0.0001004132,0.2560417,0.000003560744,0.7422898,0.000568136],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.01533132,0.03045621,0.003520474,0.5112562,0.00698803,0.006679808,0.001392724,0.0004192498,0.423956],"genre_scores_gemma":[0.1118965,0.002768961,0.0002576944,0.4269603,0.01028794,0.0001148939,0.001358575,0.0007245697,0.4456306],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.1089098,"threshold_uncertainty_score":0.9999797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01951225861638796,"score_gpt":0.2302212009821811,"score_spread":0.2107089423657932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}