{"id":"W3047822086","doi":"10.1038/s41589-020-0609-7","title":"Functional characterization of a PROTAC directed against BRAF mutant V600E","year":2020,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; Sinai Health System; Occupational Cancer Research Centre; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Ontario Institute for Cancer Research","funders":"CIHR Skin Research Training Centre; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Canada Research Chairs; U.S. Department of Health and Human Services; Government of Canada; Ontario Research Foundation; National Center for Research Resources; National Institute of General Medical Sciences; Terry Fox Research Institute; Banting Research Foundation","keywords":"MAPK/ERK pathway; Kinase; Mutant; Cancer research; V600E; Proteolysis; Cell growth; Mutation; HEK 293 cells; Synthetic lethality; Cell culture; Cell biology; Biology; Genetics; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002584843,0.0004000602,0.0002220917,0.0002789608,0.000335783,0.0004392235,0.0003732554,0.0004106874,0.001546411],"category_scores_gemma":[0.0002209023,0.0001674829,0.0003734681,0.0002143739,0.0001979715,0.0001850872,0.000152012,0.0006683621,0.0009958165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006020978,"about_ca_system_score_gemma":0.0003344134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002327467,"about_ca_topic_score_gemma":0.002151422,"domain_scores_codex":[0.9997688,0.00002547999,0.00001897523,0.00003871047,0.0001032235,0.00004486623],"domain_scores_gemma":[0.9997081,0.00004865956,0.00004998441,0.00002862469,0.00009279019,0.00007178931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005368429,0.00001880772,0.0000701718,0.00001330937,0.000003460858,0.00003833651,0.000005904431,0.00003468681,0.99922,0.00005721136,0.0000355862,0.0004488355],"study_design_scores_gemma":[0.000009322759,0.00009807477,0.001176134,0.000001965513,0.000008762684,0.0003924127,0.00001069954,0.0006536476,0.9947172,0.00001404309,0.002913881,0.000003848915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880409,0.001007454,0.007243075,0.0002280299,0.00007110219,0.00007363209,0.001106019,0.0001289285,0.002100933],"genre_scores_gemma":[0.9783695,0.0005763866,0.008670998,0.0001627537,0.00002075992,0.00003125369,0.004043785,0.00007839153,0.008046178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002327467,"threshold_uncertainty_score":0.005173266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007230765162293529,"score_gpt":0.2225583779836184,"score_spread":0.2153276128213248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}