{"id":"W3047853280","doi":"10.1158/1538-7445.pedca19-a24","title":"Abstract A24: Identifying BRCAness in osteosarcoma with DNA-methylation profiling and gene expression signatures","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Loss of heterozygosity; Biology; Synthetic lethality; DNA methylation; Genome instability; Genetics; Cancer research; Gene; Molecular biology; Allele; DNA; Gene expression; DNA repair; DNA damage","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005052359,0.0004807867,0.0005045126,0.0008405741,0.0002372855,0.0004198278,0.0002569214,0.0003116448,0.001844025],"category_scores_gemma":[0.0007377312,0.0001711519,0.0003987552,0.0006400888,0.0001329792,0.0001544941,0.0003215941,0.0001903888,0.0006946026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001765629,"about_ca_system_score_gemma":0.0002607362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001605727,"about_ca_topic_score_gemma":0.002255833,"domain_scores_codex":[0.9997111,0.00003730894,0.00002123811,0.0001427749,0.0000573159,0.00003022474],"domain_scores_gemma":[0.9997998,0.00005710807,0.00004030178,0.00002380301,0.00004787018,0.00003108195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001773056,0.0002698751,0.2886925,0.000494931,0.0003682572,0.000382951,0.0002266271,0.01329921,0.5486643,0.0002323943,0.00684859,0.1387473],"study_design_scores_gemma":[0.0002273787,0.001441515,0.5337645,0.00006319289,0.0005558943,0.001488798,0.0002941679,0.1866214,0.2598284,0.001389257,0.01422394,0.0001015012],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9681458,0.0007903926,0.01817457,0.00008219233,0.00002454448,0.0001062017,0.01032731,0.001400642,0.0009481813],"genre_scores_gemma":[0.9438841,0.0002273163,0.03503742,0.00005216978,0.00002851116,0.0001984495,0.01905549,0.0001457773,0.001370795],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.001844025,"threshold_uncertainty_score":0.006168842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0535599531067639,"score_gpt":0.3596721743655766,"score_spread":0.3061122212588127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}