{"id":"W3047886294","doi":"10.1053/j.gastro.2020.08.005","title":"Increased Intestinal Permeability Is Associated With Later Development of Crohn’s Disease","year":2020,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":310,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sinai Health System; University of Manitoba; University of Ottawa; McGill University Health Centre; McMaster University; Mount Sinai Hospital; University of Calgary; Children's Hospital of Eastern Ontario; Population Health Research Institute; University of Alberta; University of British Columbia; Hospital for Sick Children; Public Health Ontario; BC Children's Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; Childhood Cancer Canada; Canada Research Chairs; Crohn's and Colitis Canada; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Intestinal permeability; Asymptomatic; Gastroenterology; Medicine; Hazard ratio; Internal medicine; Lactulose; Crohn's disease; Biomarker; Mannitol; Proportional hazards model; Pathogenesis; Barrier function; Prospective cohort study; Disease; Confidence interval; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001091863,0.0001671207,0.0001804974,0.0000215736,0.00004380988,0.000006199156,0.0001801124,0.00006007336,0.0001172042],"category_scores_gemma":[0.0001967965,0.0001491735,0.00006813204,0.00003508329,0.0001713012,0.000003611868,0.0001380606,0.00007996969,0.00001083448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001993196,"about_ca_system_score_gemma":0.0001729229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001714812,"about_ca_topic_score_gemma":0.00005206944,"domain_scores_codex":[0.9988248,0.000131845,0.0002718153,0.0003607872,0.0001236849,0.0002871159],"domain_scores_gemma":[0.9992174,0.000006431826,0.0001269193,0.0002264065,0.0001339614,0.0002889155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00641583,0.0001755047,0.9756345,0.0000423307,0.0001255835,0.0001667787,0.0002038944,0.00002078767,0.0166174,0.000001711184,0.0005349393,0.00006074897],"study_design_scores_gemma":[0.001293288,0.000361024,0.9939795,0.00001477763,0.00004056924,0.000004986068,0.00002139591,0.0001170096,0.00385868,0.000005136149,0.0002090012,0.00009466979],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986669,0.00000744027,0.0007114594,0.0002940797,0.00002206962,0.0001736356,0.00006303687,0.00001823609,0.00004310862],"genre_scores_gemma":[0.9968219,6.44726e-7,0.000843799,0.002036474,0.00004267414,0.00002884782,0.0001896187,0.00001870334,0.00001738275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01834498,"threshold_uncertainty_score":0.6083117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00936574649141016,"score_gpt":0.2124468045712762,"score_spread":0.203081058079866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}