{"id":"W3047886294","doi":"10.1053/j.gastro.2020.08.005","title":"Increased Intestinal Permeability Is Associated With Later Development of Crohn’s Disease","year":2020,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":310,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sinai Health System; University of Manitoba; University of Ottawa; McGill University Health Centre; McMaster University; Mount Sinai Hospital; University of Calgary; Children's Hospital of Eastern Ontario; Population Health Research Institute; University of Alberta; University of British Columbia; Hospital for Sick Children; Public Health Ontario; BC Children's Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; Childhood Cancer Canada; Canada Research Chairs; Crohn's and Colitis Canada; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Intestinal permeability; Asymptomatic; Gastroenterology; Medicine; Hazard ratio; Internal medicine; Lactulose; Crohn's disease; Biomarker; Mannitol; Proportional hazards model; Pathogenesis; Barrier function; Prospective cohort study; Disease; Confidence interval; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004350599,0.000603257,0.0007506784,0.002108301,0.0005186657,0.001179984,0.0004426725,0.001021813,0.002394876],"category_scores_gemma":[0.002872062,0.0003965461,0.000616921,0.001505162,0.0005405606,0.0005780295,0.0006542155,0.001678517,0.0003643273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002656122,"about_ca_system_score_gemma":0.0002387907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008599292,"about_ca_topic_score_gemma":0.0005737435,"domain_scores_codex":[0.9995314,0.0001440643,0.0000481343,0.00008839071,0.00007711502,0.0001108982],"domain_scores_gemma":[0.9950559,0.0007672739,0.002541973,0.0002190243,0.0002531403,0.001162597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002036668,0.0001619509,0.9748293,0.0000695494,0.0001328048,0.00518931,0.000117732,0.00007294896,0.01331575,0.000132234,0.0001172125,0.003824404],"study_design_scores_gemma":[0.000006205745,0.0001789113,0.9948103,0.000009076609,0.00004219371,0.003964659,0.00006186431,0.00008669113,0.0005978959,0.00006148676,0.0001740674,0.000006561822],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967379,0.001352365,0.0002475606,0.0001010125,0.00003035347,0.000004614353,0.0001218589,0.00002949027,0.001374866],"genre_scores_gemma":[0.9988587,0.0003760265,0.0001943054,0.00001883592,0.00004272503,0.000003415292,0.0001214375,0.000008307274,0.0003761926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002394876,"threshold_uncertainty_score":0.008011699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00936574649141016,"score_gpt":0.2124468045712762,"score_spread":0.203081058079866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}