{"id":"W3047911986","doi":"10.15252/emmm.202012308","title":"Higher CSF sTREM2 and microglia activation are associated with slower rates of beta‐amyloid accumulation","year":2020,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Deutsche Forschungsgemeinschaft; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Microglia; Amyloid (mycology); BETA (programming language); Amyloid beta; Chemistry; Neuroscience; Medicine; Inflammation; Immunology; Internal medicine; Pathology; Biology; Disease; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009660609,0.0001652774,0.0002392247,0.00008191,0.00007447091,0.00002147728,0.00009736286,0.00005819125,0.0001717477],"category_scores_gemma":[0.0006424566,0.0001325029,0.00002512232,0.0003908668,0.00009334503,0.0001700477,0.00002947803,0.000134561,0.00000591056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001215612,"about_ca_system_score_gemma":0.00002073321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002540902,"about_ca_topic_score_gemma":0.000001267003,"domain_scores_codex":[0.9986081,0.0001816281,0.0002833606,0.0003713521,0.0004156925,0.0001399132],"domain_scores_gemma":[0.9991862,0.0001233614,0.0003074731,0.0001537214,0.0001114248,0.0001177729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005749273,0.00002232133,0.0002496371,0.00001836343,0.000008245827,0.00002372872,0.000205657,0.0001630981,0.9971252,0.001725726,0.0002538295,0.000146692],"study_design_scores_gemma":[0.001254801,0.0002982874,0.005978063,0.000069681,0.00003115794,0.000002970064,0.00003606492,0.001670975,0.9900513,0.0001345697,0.0003501702,0.00012194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853348,0.0000273733,0.003187554,0.01050933,0.0001008263,0.000296939,0.000007364387,0.00008263785,0.0004531427],"genre_scores_gemma":[0.9927434,0.00001399107,0.00009557727,0.006878565,0.00006407198,0.000006662954,0.00002348714,0.00002720507,0.0001470569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007408551,"threshold_uncertainty_score":0.5403312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06052003984818304,"score_gpt":0.2901994969512472,"score_spread":0.2296794571030641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}