{"id":"W3047911986","doi":"10.15252/emmm.202012308","title":"Higher CSF sTREM2 and microglia activation are associated with slower rates of beta‐amyloid accumulation","year":2020,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Deutsche Forschungsgemeinschaft; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Microglia; Amyloid (mycology); BETA (programming language); Amyloid beta; Chemistry; Neuroscience; Medicine; Inflammation; Immunology; Internal medicine; Pathology; Biology; Disease; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002489454,0.0004299634,0.0003154264,0.0005421901,0.0001824438,0.0004303404,0.0001280771,0.0004682366,0.002076139],"category_scores_gemma":[0.000645893,0.0001659593,0.0002287687,0.0002283747,0.0001769195,0.0002383348,0.0002340048,0.0004323202,0.0003207343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001633321,"about_ca_system_score_gemma":0.0001136509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007143278,"about_ca_topic_score_gemma":0.0005344954,"domain_scores_codex":[0.9998862,0.00001667209,0.000009925603,0.00004004373,0.00002318891,0.00002401352],"domain_scores_gemma":[0.9993415,0.00005937662,0.000370223,0.00003978431,0.00006986142,0.000119192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007695346,0.000361131,0.4658201,0.0001452545,0.0002311395,0.002208831,0.0004212188,0.0002714304,0.5089179,0.0001882637,0.0005087754,0.01323075],"study_design_scores_gemma":[0.0000205017,0.000393044,0.9785558,0.00001165855,0.00003762385,0.002134898,0.0001061276,0.0003393527,0.01783238,0.0001524148,0.0004060476,0.00001016879],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991603,0.0002549168,0.0002028946,0.00001873306,0.000005521363,0.000003537131,0.0001544676,0.00001255985,0.0001871304],"genre_scores_gemma":[0.9989516,0.00007241657,0.0002134886,0.00001965053,0.00000788215,0.000008419707,0.000186571,0.000005554694,0.0005345584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002076139,"threshold_uncertainty_score":0.006945431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06052003984818304,"score_gpt":0.2901994969512472,"score_spread":0.2296794571030641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}