{"id":"W3047944543","doi":"10.3390/cells9081863","title":"Genomic Analysis of Localized High-Risk Prostate Cancer Circulating Tumor Cells at the Single-Cell Level","year":2020,"lang":"en","type":"article","venue":"Cells","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Atlantic Cancer Research Institute; University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Prostate Cancer Fight Foundation","keywords":"Prostate cancer; Circulating tumor cell; Exome sequencing; Prostate; Indel; Cancer; Biology; Oncology; Medicine; Internal medicine; Single-nucleotide polymorphism; Genetics; Gene; Mutation; Genotype; Metastasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001172676,0.0001720575,0.0002863026,0.00003321121,0.00009241205,0.00002583761,0.0002261376,0.00006803994,0.0001402892],"category_scores_gemma":[0.00004107932,0.0001434889,0.0002207188,0.0002619274,0.00009937592,0.000001566025,0.0002282984,0.00008375457,0.00001893603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005166738,"about_ca_system_score_gemma":0.0001039265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005946767,"about_ca_topic_score_gemma":0.0003330871,"domain_scores_codex":[0.9988388,0.00005379414,0.0003535017,0.0003922089,0.0001185993,0.0002430471],"domain_scores_gemma":[0.9990503,0.00006773703,0.000328449,0.0003644783,0.00008100087,0.000108033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007754092,0.00003565198,0.003525026,0.00003022175,0.0003021682,0.000003410091,0.0002506339,0.06063215,0.9321385,0.000002798459,0.002192046,0.0008098506],"study_design_scores_gemma":[0.0006098713,0.0001186659,0.001361249,0.000004774628,0.0007268229,3.665758e-7,0.000076902,0.002703231,0.9704111,0.000007449692,0.02378118,0.0001983623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950013,0.002106082,0.0008011226,0.0001565408,0.0001686566,0.000238664,0.001289558,0.000006380595,0.0002316588],"genre_scores_gemma":[0.9970288,0.0009238383,0.000407264,0.0008887024,0.0001704198,0.00001684045,0.0001613137,0.00003235977,0.0003704292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05792892,"threshold_uncertainty_score":0.5851309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01685171683500446,"score_gpt":0.2216527630120889,"score_spread":0.2048010461770844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}