{"id":"W3048067521","doi":"10.1080/10428194.2020.1795159","title":"Final 5-year findings from the phase 3 HELIOS study of ibrutinib plus bendamustine and rituximab in patients with relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma","year":2020,"lang":"en","type":"article","venue":"Leukemia & lymphoma/Leukemia and lymphoma","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Cancer Centre","funders":"National Cancer Institute","keywords":"Ibrutinib; Bendamustine; Medicine; Chronic lymphocytic leukemia; Internal medicine; Rituximab; Ofatumumab; Placebo; Hazard ratio; Alemtuzumab; Oncology; Lymphoma; Gastroenterology; Leukemia; Confidence interval; Transplantation; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0009896046,0.00210317,0.003424658,0.0007699098,0.0007686579,0.0003549491,0.001531546,0.00105872,0.0002029686],"category_scores_gemma":[0.0009600634,0.001656651,0.0004290025,0.002602152,0.001684399,0.00076607,0.00137397,0.0006627818,0.0001425075],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.2204884,"about_ca_system_score_gemma":0.09826215,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02160492,"about_ca_topic_score_gemma":0.00105238,"domain_scores_codex":[0.9877979,0.0006744865,0.002824403,0.003297806,0.002795586,0.002609821],"domain_scores_gemma":[0.9923826,0.001878642,0.001012207,0.002369057,0.0006169433,0.001740519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2422094,0.01823372,0.2252589,0.009602859,0.00877781,0.0145823,0.07436112,0.006352284,0.006639963,0.0008586314,0.009038593,0.3840843],"study_design_scores_gemma":[0.71899,0.01106103,0.1629147,0.001838296,0.001585223,0.0007053579,0.005060341,0.0910971,0.001999091,0.00005971261,0.002526033,0.002163067],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901012,0.003717908,0.00005071364,0.0001879773,0.0003052713,0.004481805,0.0003289165,0.0003714549,0.0004547509],"genre_scores_gemma":[0.9950026,0.0009059439,0.0004417398,0.001415913,0.0007031354,0.0003613669,0.0004661717,0.0004321239,0.0002710269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4767806,"threshold_uncertainty_score":0.999171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02279744231098206,"score_gpt":0.2582515279847478,"score_spread":0.2354540856737657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}