{"id":"W3048086364","doi":"10.1016/j.isci.2020.101447","title":"Alternative Splicing of a Receptor Intracellular Domain Yields Different Ectodomain Conformations, Enabling Isoform-Selective Functional Ligands","year":2020,"lang":"en","type":"article","venue":"iScience","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Research Council Canada; Canadian Institutes of Health Research; Consortium canadien en neurodégénérescence associée au vieillissement","keywords":"Ectodomain; Gene isoform; Intracellular; Cell biology; Chemistry; Signal transduction; Alternative splicing; Receptor; Biochemistry; Biology; Biophysics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002121229,0.0002406759,0.0001568665,0.00009218278,0.00009733393,0.0003170342,0.0002071182,0.0001746016,0.00111716],"category_scores_gemma":[0.0001676828,0.0001079646,0.0002786822,0.00009786153,0.0002137092,0.0001773635,0.000152757,0.0005710375,0.0004516898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000214517,"about_ca_system_score_gemma":0.0001610281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001891659,"about_ca_topic_score_gemma":0.0003700204,"domain_scores_codex":[0.9998646,0.00003277443,0.00001936988,0.0000308423,0.00002904315,0.00002328736],"domain_scores_gemma":[0.9998078,0.00003957792,0.00004740969,0.00005710804,0.00002244083,0.00002572772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004160056,0.00001129738,0.0001964776,0.000009588088,0.000004424661,0.00005684171,0.00001113961,0.0000602596,0.9978526,0.0004352019,0.00002330524,0.001297308],"study_design_scores_gemma":[0.000009824535,0.0001087822,0.001151507,0.000003014693,0.00001608122,0.0004182915,0.00001908356,0.0007944517,0.994752,0.0001162782,0.002606309,0.000004217131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829212,0.0003241244,0.01418547,0.00009053883,0.00005177575,0.00002733591,0.0002745808,0.00004877226,0.002076288],"genre_scores_gemma":[0.9915392,0.0002534317,0.005933715,0.00007187361,0.0000118065,0.00001448343,0.0004430036,0.000037563,0.001694997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00111716,"threshold_uncertainty_score":0.00373733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01575562618408611,"score_gpt":0.2276567713525642,"score_spread":0.2119011451684781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}