{"id":"W3048086364","doi":"10.1016/j.isci.2020.101447","title":"Alternative Splicing of a Receptor Intracellular Domain Yields Different Ectodomain Conformations, Enabling Isoform-Selective Functional Ligands","year":2020,"lang":"en","type":"article","venue":"iScience","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Research Council Canada; Canadian Institutes of Health Research; Consortium canadien en neurodégénérescence associée au vieillissement","keywords":"Ectodomain; Gene isoform; Intracellular; Cell biology; Chemistry; Signal transduction; Alternative splicing; Receptor; Biochemistry; Biology; Biophysics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002293696,0.0001307872,0.0001522972,0.00004391641,0.0001426879,0.00003170758,0.0002005758,0.00007916374,0.0001045426],"category_scores_gemma":[0.0001023191,0.0001110618,0.0000790316,0.0001831767,0.00008486158,0.00001798663,0.00009847862,0.0001105342,0.000007434989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002103482,"about_ca_system_score_gemma":0.00007090637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001489851,"about_ca_topic_score_gemma":0.000003168131,"domain_scores_codex":[0.9989681,0.00002684894,0.0002557017,0.0002918185,0.0002429202,0.0002146389],"domain_scores_gemma":[0.9994927,0.00002354448,0.0001501859,0.0001195248,0.0001099656,0.0001041033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005768709,0.00002145326,0.0002145,0.00001228631,0.00001999959,4.684881e-7,0.0009035491,0.001103315,0.9953197,0.001337406,0.0001630931,0.0008465921],"study_design_scores_gemma":[0.000305315,0.0002991476,0.00008492918,0.00002132352,0.000005863418,0.000003387878,0.0006525659,0.002971248,0.9939213,0.0005263928,0.001071768,0.0001367774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7580092,0.0001845115,0.241059,0.0001898331,0.0001332695,0.0001214111,0.00001112855,0.000008648661,0.000283047],"genre_scores_gemma":[0.9979246,0.00007753626,0.001409542,0.0002694124,0.0002119586,0.00001300278,0.00003169634,0.000009016564,0.00005317997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2399155,"threshold_uncertainty_score":0.4528971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01575562618408611,"score_gpt":0.2276567713525642,"score_spread":0.2119011451684781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}