{"id":"W3048088609","doi":"10.1139/cjpp-2019-0585","title":"Combined treatment of menadione and calcitriol increases the antiproliferative effect by promoting oxidative/nitrosative stress, mitochondrial dysfunction, and autophagy in breast cancer MCF-7 cells","year":2020,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Vitamin C and Antioxidants Research","field":"Nursing","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute","keywords":"Menadione; Calcitriol; Autophagy; Oxidative stress; Mitochondrion; Apoptosis; Nitric oxide; MCF-7; Oxidative phosphorylation; Chemistry; Cancer cell; Pharmacology; Cell biology; Cancer research; Endocrinology; Internal medicine; Biology; Cancer; Biochemistry; Medicine; Vitamin D and neurology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001633566,0.0001623769,0.0004624559,0.0001090129,0.0002082405,0.00001458668,0.00007776525,0.00009258637,0.0001536377],"category_scores_gemma":[0.00004380171,0.0001081951,0.00003699871,0.0001446055,0.00061544,0.000106188,0.00001559408,0.0002673102,3.490496e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006853399,"about_ca_system_score_gemma":0.0002233085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004302506,"about_ca_topic_score_gemma":0.0009514699,"domain_scores_codex":[0.9981936,0.0009819211,0.0002868047,0.0001994179,0.00006096755,0.000277258],"domain_scores_gemma":[0.9987692,0.0005305829,0.0002115429,0.00003618254,0.0001072787,0.0003451772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001727079,0.00007081898,0.02597249,0.0001065247,0.00020471,0.00003548607,0.002833556,0.00002147347,0.9651048,0.000008946416,0.001108932,0.002805142],"study_design_scores_gemma":[0.006515208,0.003569241,0.07102283,0.00007057295,0.0001586615,0.00005590541,0.0003476256,0.0008674031,0.9169825,0.00009154716,0.0001914234,0.0001270227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921015,0.002459177,0.000004249879,0.004436199,0.0002690419,0.0003959004,0.0003275867,0.000002247152,0.000004096316],"genre_scores_gemma":[0.9986796,0.000616483,0.00001000518,0.0003902118,0.0002638509,0.00001604599,0.000007610613,0.000009263755,0.00000690316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04812228,"threshold_uncertainty_score":0.6504131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01044797693227547,"score_gpt":0.2795249524691686,"score_spread":0.2690769755368931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}