{"id":"W3048097005","doi":"10.1038/s41598-020-70231-7","title":"Myeloid-derived suppressor cell depletion therapy targets IL-17A-expressing mammary carcinomas","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Beatrice Hunter Cancer Research Institute; Capital District Health Authority; Dalhousie University","funders":"QEII Foundation; Breast Cancer Society of Canada","keywords":"Cancer research; Immune system; Myeloid-derived Suppressor Cell; Cytokine; Metastasis; CD8; Myeloid; Immunotherapy; Interleukin 17; Biology; Medicine; Immunology; Cancer; Suppressor; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000120087,0.0002517087,0.000432313,0.0002571263,0.00008636522,0.0002627596,0.0001582937,0.0001828674,0.0012073],"category_scores_gemma":[0.00007621796,0.00008140125,0.0002076462,0.0001206839,0.0001704824,0.0001183556,0.0001519397,0.0007324758,0.0004337762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001463985,"about_ca_system_score_gemma":0.0002416267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001489411,"about_ca_topic_score_gemma":0.000307607,"domain_scores_codex":[0.9999199,0.00001093168,0.000005618997,0.00001161799,0.00001997076,0.00003188507],"domain_scores_gemma":[0.9999486,0.000007634471,0.00001494788,0.000006715945,0.000005001278,0.00001708304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007768758,0.0005527303,0.0003921906,0.0001131139,0.00001394296,0.0001642653,0.00004431284,0.0002142967,0.9826924,0.0002575136,0.0002416693,0.01453668],"study_design_scores_gemma":[0.0003170962,0.007575023,0.003980427,0.0000402171,0.00008501951,0.0009372697,0.00009387801,0.002330668,0.9656456,0.0001921533,0.01879406,0.000008499475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938559,0.00215676,0.001524635,0.0001314938,0.0001038002,0.0001159015,0.0002211827,0.0001340996,0.001756199],"genre_scores_gemma":[0.9936092,0.001861292,0.001214734,0.00007291728,0.00003084416,0.0001215519,0.0002763668,0.00001764029,0.00279546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0012073,"threshold_uncertainty_score":0.004038811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01914206935307698,"score_gpt":0.2261081283881662,"score_spread":0.2069660590350893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}