{"id":"W3048108137","doi":"10.1186/s13059-020-02115-y","title":"The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation","year":2020,"lang":"en","type":"article","venue":"Genome biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research; University of Toronto","funders":"National Human Genome Research Institute; Xiangya Hospital, Central South University; National Institutes of Health; Cancer Prevention and Research Institute of Texas; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo; Central South University; Deutscher Akademischer Austauschdienst","keywords":"Biology; Epigenetics; Gene knockdown; RNA-binding protein; Gene silencing; Glioma; Regulation of gene expression; Cancer research; Phenotype; Regulator; Cancer stem cell; Genetics; Cancer; Gene; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000098442,0.0003991863,0.0001994996,0.0002151811,0.0001843402,0.0002237011,0.0001707505,0.0001938215,0.001036156],"category_scores_gemma":[0.00006404309,0.00008857524,0.0001801341,0.0001624436,0.0001953453,0.00009408523,0.0001609224,0.0002823785,0.0004032943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003889122,"about_ca_system_score_gemma":0.0002120895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000601786,"about_ca_topic_score_gemma":0.000957933,"domain_scores_codex":[0.9999517,0.000005102372,0.000002700791,0.00001171045,0.00001662527,0.00001220545],"domain_scores_gemma":[0.9999536,0.000003753112,0.00001689402,0.000003295376,0.000005693431,0.00001669487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001576444,0.00001763363,0.001010846,0.0001025223,0.000008086599,0.0001981197,0.00001064157,0.0001176025,0.9927258,0.0001964813,0.0002208581,0.005233792],"study_design_scores_gemma":[0.0000213926,0.0003652252,0.03022403,0.00002464019,0.00006572653,0.001832466,0.00003929444,0.001593994,0.9526672,0.0002661874,0.01289072,0.000009226149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757591,0.0117267,0.007030169,0.0004551029,0.00008329188,0.00002817329,0.0009295967,0.0005263155,0.003461539],"genre_scores_gemma":[0.9915906,0.002789846,0.002502972,0.00008098645,0.00001739183,0.0000167322,0.0007485074,0.00003149806,0.002221436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001036156,"threshold_uncertainty_score":0.003466308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01473207650185591,"score_gpt":0.2657769968465644,"score_spread":0.2510449203447085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}