{"id":"W3048136450","doi":"10.1093/nar/gkaa662","title":"Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5′ leader regions","year":2020,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Biology; Identification (biology); Genetics; Mutant; Computational biology; Messenger RNA; Gene; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001226117,0.000268733,0.0002194178,0.0002143483,0.0001158668,0.0002088763,0.0002023286,0.0002010728,0.0008343267],"category_scores_gemma":[0.0001860589,0.0001211755,0.0002556138,0.0002121963,0.0001574203,0.0000991153,0.0001515145,0.0004663757,0.0005269051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002565124,"about_ca_system_score_gemma":0.0001671273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007990851,"about_ca_topic_score_gemma":0.001243494,"domain_scores_codex":[0.9998823,0.00001491175,0.00001486637,0.00002088289,0.00004540896,0.00002148599],"domain_scores_gemma":[0.9998011,0.00004345143,0.00008101996,0.00001989968,0.0000208208,0.00003369885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003018057,0.00001509663,0.0000886707,0.00001272396,0.000002990827,0.0000460579,0.000008274289,0.00007399281,0.9989599,0.00005443627,0.0000284393,0.0006792466],"study_design_scores_gemma":[0.000009257205,0.0001577741,0.003798963,0.000004614074,0.00001290384,0.0003352212,0.00002602469,0.001150239,0.9916188,0.00003924537,0.002839898,0.000007108489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885434,0.0006643442,0.006949774,0.0001275788,0.00003542884,0.00006095235,0.002093005,0.0001612336,0.001364247],"genre_scores_gemma":[0.9846181,0.0006619291,0.006666126,0.00006675607,0.00001039628,0.00006919702,0.003179351,0.0001607978,0.004567367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008343267,"threshold_uncertainty_score":0.002791047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06191721458236957,"score_gpt":0.3301146096904152,"score_spread":0.2681973951080456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}