{"id":"W3048148439","doi":"10.1158/1538-7445.pedca19-b37","title":"Abstract B37: Menin and EWS/FLI1 activate serine biosynthesis via ATF4 in Ewing sarcoma","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Gene knockdown; Cancer research; FLI1; Transcription factor; Biology; ATF4; Oncogene; Cancer; Genetics; Gene; Cell cycle","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001072084,0.0002688212,0.0002204909,0.0002340073,0.0001898877,0.0001885352,0.0001717819,0.0002253196,0.002591009],"category_scores_gemma":[0.00005916678,0.000108973,0.0002713509,0.0001339077,0.0002214478,0.0002040334,0.0001815683,0.000444216,0.0005644737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004484293,"about_ca_system_score_gemma":0.0002057495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007289696,"about_ca_topic_score_gemma":0.0007574921,"domain_scores_codex":[0.9999123,0.00001189989,0.0000136054,0.00002004605,0.00002151411,0.00002079912],"domain_scores_gemma":[0.9999449,0.000007681519,0.00001542974,0.000006213249,0.000003628126,0.00002220183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000112209,0.00002098417,0.0001422043,0.00002725529,0.000002592233,0.00005186207,0.00000641831,0.00004376251,0.9989177,0.00009678904,0.0000521102,0.0005261007],"study_design_scores_gemma":[0.00001605738,0.0001027009,0.003623773,0.000002916651,0.000005897863,0.0001599844,0.0000187073,0.0005012459,0.9935936,0.00004356027,0.001929319,0.000002131779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904271,0.002170846,0.002789483,0.0002639945,0.00005172516,0.00003521004,0.001486474,0.0001483945,0.002626796],"genre_scores_gemma":[0.9925306,0.0005529147,0.001469036,0.00009358954,0.0000101499,0.00003093897,0.001197668,0.00001721033,0.004097821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002591009,"threshold_uncertainty_score":0.008667827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06065981817003113,"score_gpt":0.3554778057143165,"score_spread":0.2948179875442853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}