{"id":"W3048149014","doi":"10.1177/1060028020948174","title":"Effect of Therapeutic Drug Monitoring and Cytochrome P450 2C19 Genotyping on Clinical Outcomes of Voriconazole: A Systematic Review","year":2020,"lang":"en","type":"review","venue":"Annals of Pharmacotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"","keywords":"Voriconazole; Medicine; Therapeutic drug monitoring; CYP2C19; Dosing; Internal medicine; Pharmacology; Randomized controlled trial; Pharmacogenetics; Intensive care medicine; Pharmacokinetics; Genotype; Cytochrome P450; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003287928,0.0005751502,0.009057115,0.0001546647,0.00002993235,0.000006239225,0.0003099779,0.0001877828,0.00005075382],"category_scores_gemma":[0.0005061309,0.0003583604,0.00189248,0.0003696727,0.0001801121,0.00005366362,0.00004006469,0.0005450953,0.000009456784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002691503,"about_ca_system_score_gemma":0.0002050901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009594838,"about_ca_topic_score_gemma":1.986598e-7,"domain_scores_codex":[0.9944413,0.001456251,0.002720029,0.0005075322,0.0006006169,0.0002743276],"domain_scores_gemma":[0.9943285,0.002721331,0.001892404,0.0006438125,0.0002240168,0.0001899229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0002650863,0.0001607937,0.001494996,0.802133,0.00263144,0.00001170518,0.00005057577,2.683243e-8,0.0005816495,0.000009770126,0.00008309566,0.1925778],"study_design_scores_gemma":[0.001575192,0.002413975,0.001414999,0.9683303,0.01017946,0.00001269681,0.00001261262,0.000002935851,0.003670906,0.000009139105,0.01196515,0.0004126907],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003939057,0.9915949,0.000006264511,0.0001483095,0.0001276785,0.004061787,0.00004857227,0.00002476622,0.00004873323],"genre_scores_gemma":[0.01603048,0.9830002,0.00002079062,0.0005523172,0.000140299,0.00009625457,0.000007973976,0.00007074499,0.00008090006],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1921651,"threshold_uncertainty_score":0.9998868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1620748648944884,"score_gpt":0.5290984439273729,"score_spread":0.3670235790328845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}