{"id":"W3048232459","doi":"10.1038/s41416-020-1025-1","title":"Broccoli extract increases drug-mediated cytotoxicity towards cancer stem cells of head and neck squamous cell carcinoma","year":2020,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Egyptian Cultural and Educational Bureau","keywords":"Cancer research; Viability assay; Sulforaphane; SOX2; Cancer stem cell; Head and neck squamous-cell carcinoma; CD44; Cisplatin; In vivo; Stem cell; Cancer cell; Cytotoxicity; Cancer; Cell; Biology; Medicine; Head and neck cancer; Internal medicine; In vitro; Embryonic stem cell; Chemotherapy; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001146222,0.0002773008,0.0003571309,0.0004253456,0.000140533,0.0001805745,0.0001271701,0.0002334326,0.002366385],"category_scores_gemma":[0.0001171212,0.0000914006,0.0002824108,0.0001850743,0.0001262458,0.0001721919,0.0001183509,0.0004500527,0.0003146701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001753208,"about_ca_system_score_gemma":0.0002224034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009174643,"about_ca_topic_score_gemma":0.001634687,"domain_scores_codex":[0.999923,0.00001869929,0.000009295463,0.00001365697,0.00001877477,0.00001656716],"domain_scores_gemma":[0.9998968,0.00002995822,0.00001889837,0.000009699414,0.00002182152,0.00002281045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005030532,0.0001236233,0.0003068967,0.000089594,0.00001505353,0.00003763674,0.00002587406,0.00003574795,0.9965088,0.00001955388,0.00006399667,0.002270112],"study_design_scores_gemma":[0.00006151346,0.002939776,0.01152518,0.00002095566,0.00007321133,0.0002077999,0.00004816647,0.0003146887,0.9823208,0.0000249791,0.002456803,0.000006172032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945548,0.003387449,0.0004200277,0.00007132484,0.00002437247,0.00004213213,0.000310568,0.00006500478,0.001124347],"genre_scores_gemma":[0.9949232,0.001580115,0.000689542,0.00005303716,0.0000150758,0.00003996436,0.0007351433,0.00001508707,0.001948862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002366385,"threshold_uncertainty_score":0.007916391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01261272922599089,"score_gpt":0.2469690601351802,"score_spread":0.2343563309091894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}