{"id":"W3048255749","doi":"10.1158/1538-7445.pedca19-b69","title":"Abstract B69: Epigenomics and single-cell sequencing define a developmental hierarchy in Langerhans cell histiocytosis","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histiocytic Disorders and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Langerhans cell histiocytosis; Biology; Lineage markers; Chromatin; Epigenomics; Phenotype; Cancer research; Genetics; Pathology; Gene expression; Gene; Disease; DNA methylation; Medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002729347,0.000236492,0.0003130668,0.000581551,0.0002369879,0.000513846,0.0001912935,0.0002959447,0.001643647],"category_scores_gemma":[0.0004248117,0.0001768264,0.0002822173,0.000497636,0.0002285215,0.0002234862,0.0002611921,0.0004245172,0.0006756899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002283758,"about_ca_system_score_gemma":0.0001971549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009712716,"about_ca_topic_score_gemma":0.001620201,"domain_scores_codex":[0.9997907,0.00002171469,0.000009480593,0.0000920302,0.00005108612,0.00003484316],"domain_scores_gemma":[0.9996804,0.0001127515,0.00007606827,0.00003311563,0.00005676944,0.00004095416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001097436,0.00001638427,0.007264934,0.00006599042,0.00002557042,0.00007795374,0.00006378571,0.0007324882,0.9842256,0.0004655381,0.0002485643,0.006703468],"study_design_scores_gemma":[0.00002701008,0.0002484507,0.5636127,0.00004518478,0.0001645153,0.0008563746,0.0002708133,0.04283287,0.3723709,0.004572046,0.0149379,0.00006125172],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9425336,0.00104023,0.04488764,0.0001393498,0.00002999205,0.00003618505,0.008173178,0.0006304477,0.002529388],"genre_scores_gemma":[0.9624925,0.0004797999,0.02621661,0.0002055172,0.00002301586,0.00007623401,0.008714118,0.000270598,0.001521503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001643647,"threshold_uncertainty_score":0.005498588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1546364319202632,"score_gpt":0.3464227155194194,"score_spread":0.1917862835991561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}