{"id":"W3048288662","doi":"10.3390/bioengineering7030091","title":"Progress in Delivery of siRNA-Based Therapeutics Employing Nano-Vehicles for Treatment of Prostate Cancer","year":2020,"lang":"en","type":"review","venue":"Bioengineering","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"Small interfering RNA; Gene silencing; Prostate cancer; Gene knockdown; Cancer; RNA interference; Oncogene; Cancer research; Medicine; Biology; RNA; Internal medicine; Gene; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003705478,0.0002608205,0.0007101624,0.00009047504,0.00001001809,0.00000667648,0.0001457505,0.0001711488,0.000001038052],"category_scores_gemma":[0.000003781796,0.0002164276,0.0003005256,0.0001083302,0.00003329958,0.000002027662,0.00002571431,0.00003080917,3.138265e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004342094,"about_ca_system_score_gemma":0.000226244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001635363,"about_ca_topic_score_gemma":0.00001097268,"domain_scores_codex":[0.9990721,0.00001813073,0.0004049438,0.0002589273,0.00006408297,0.0001817518],"domain_scores_gemma":[0.999522,0.00001793737,0.0001830277,0.0001812896,0.00006450695,0.00003120632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006519983,0.00008475358,0.0003829934,0.007766563,0.0003393499,0.000002914311,0.00006149999,0.000256736,0.0139736,0.000001758725,0.000009364746,0.9770553],"study_design_scores_gemma":[0.000780915,0.001438264,0.00002440245,0.006062084,0.0004407035,0.000002247867,0.00002256745,0.0006864512,0.1515035,8.717819e-7,0.8385852,0.0004527966],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0267793,0.9721022,0.0001147408,0.00001032712,0.00009358172,0.0006623542,0.0002283138,0.000007553572,0.000001593039],"genre_scores_gemma":[0.02743866,0.9713709,0.0005591401,0.000006939766,0.00008501609,0.0003364162,0.0001401696,0.00004649377,0.00001630666],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9766025,"threshold_uncertainty_score":0.8825662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05005356711435269,"score_gpt":0.3278308443482067,"score_spread":0.277777277233854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}