{"id":"W3048365042","doi":"10.1038/s41467-020-17705-4","title":"Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"European Regional Development Fund; Instituto de Salud Carlos III; Agència de Gestió d'Ajuts Universitaris i de Recerca; Generalitat de Catalunya; Vallee Foundation; European Commission; Centres de Recerca de Catalunya","keywords":"Uniporter; Calcium; Mitochondrion; Biology; Evolutionary biology; Computational biology; Cell biology; Chemistry; Biochemistry; Cytosol; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002056732,0.0002360989,0.0002466434,0.0004742524,0.000335742,0.0005058966,0.0001862428,0.0004711012,0.0007872994],"category_scores_gemma":[0.000315733,0.0001252307,0.0002238048,0.0004050203,0.0002612337,0.000474749,0.0003701704,0.0003782681,0.0003140524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000187892,"about_ca_system_score_gemma":0.0001158519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004504405,"about_ca_topic_score_gemma":0.0009896839,"domain_scores_codex":[0.999905,0.00001105346,0.000007020735,0.00004234283,0.00001411708,0.00002045869],"domain_scores_gemma":[0.9996585,0.00008073244,0.0001055841,0.00005898957,0.00003540503,0.00006084498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004253989,0.00002129974,0.01339896,0.0001169306,0.00002184917,0.0004313898,0.0001338679,0.0002071721,0.9674467,0.0009531805,0.00008810574,0.01675515],"study_design_scores_gemma":[0.00004466653,0.0005830936,0.6004347,0.0001762821,0.0001537496,0.005562791,0.0007218027,0.004013196,0.3401997,0.002632359,0.04541293,0.00006482878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914039,0.001819808,0.004791647,0.00009620879,0.00002044629,0.000008345507,0.0004503373,0.00007385369,0.001335413],"genre_scores_gemma":[0.9942777,0.000685272,0.003587353,0.00006406621,0.000014302,0.000003624627,0.0005582758,0.00001578337,0.0007936599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007872994,"threshold_uncertainty_score":0.00263375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02635501871907629,"score_gpt":0.2657259517010807,"score_spread":0.2393709329820044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}