{"id":"W3048405736","doi":"10.1093/cid/ciaa1037","title":"Clinical Effectiveness of Integrase Strand Transfer Inhibitor–Based Antiretroviral Regimens Among Adults With Human Immunodeficiency Virus: A Collaboration of Cohort Studies in the United States and Canada","year":2020,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of British Columbia","funders":"National Institute on Minority Health and Health Disparities; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; National Institute on Aging; National Eye Institute; National Institute on Drug Abuse; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Alcohol Abuse and Alcoholism; National Cancer Institute; National Institutes of Health; Agency for Healthcare Research and Quality; National Center for Advancing Translational Sciences; Health Resources and Services Administration","keywords":"Dolutegravir; Medicine; Hazard ratio; Integrase inhibitor; Regimen; Internal medicine; Efavirenz; Raltegravir; Cohort; Confidence interval; Viral load; Virology; Human immunodeficiency virus (HIV); Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01678731,0.00068065,0.001087073,0.002362606,0.002612034,0.002578856,0.001892597,0.0005254311,0.001252905],"category_scores_gemma":[0.02294766,0.0005438464,0.002801384,0.005940422,0.0007757479,0.0004751325,0.002007913,0.0007638638,0.00009989392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01734521,"about_ca_system_score_gemma":0.03860769,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9645572,"about_ca_topic_score_gemma":0.9711605,"domain_scores_codex":[0.9909742,0.00270995,0.001070612,0.001559222,0.002768215,0.0009176561],"domain_scores_gemma":[0.9737259,0.004084855,0.005576204,0.002400023,0.01184098,0.002371889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000306565,0.00001781486,0.9910251,0.0001204285,0.001969443,0.00003055602,0.0002979673,0.0001681537,0.0000491254,0.0001957286,0.001037748,0.004781517],"study_design_scores_gemma":[0.00009318989,0.00005161687,0.9941314,0.0002517166,0.001623005,0.00007206852,0.0005204718,0.0006751477,0.00009705698,0.0001096016,0.002344516,0.00003025626],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9441586,0.02378719,0.001521457,0.001442943,0.0001261825,0.0005878494,0.02400411,0.00003839962,0.004333408],"genre_scores_gemma":[0.9862823,0.005519796,0.001276048,0.0003089703,0.00002187648,0.0001655035,0.00590456,0.00001613867,0.0005049111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03544283,"threshold_uncertainty_score":0.1258489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02591574977203281,"score_gpt":0.3415371510618079,"score_spread":0.3156214012897751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}