{"id":"W3048409758","doi":"10.1159/000509217","title":"Resveratrol Inhibits Neointimal Growth after Arterial Injury in High-Fat-Fed Rodents: The Roles of SIRT1 and AMPK","year":2020,"lang":"en","type":"article","venue":"Journal of Vascular Research","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Brock University; Ottawa Hospital; University of Manitoba; Children's Hospital Research Institute of Manitoba; Ontario Institute for Cancer Research; Toronto General Hospital; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Banting and Best Diabetes Centre, University of Toronto; Novo Nordisk; Heart and Stroke Foundation of Canada","keywords":"Neointimal hyperplasia; Internal medicine; Endocrinology; Insulin; AMPK; Enos; Resveratrol; Insulin resistance; Nitric oxide; AMP-activated protein kinase; Sirtuin 1; Medicine; Chemistry; Nitric oxide synthase; Downregulation and upregulation; Protein kinase A; Kinase; Restenosis; Pharmacology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000242876,0.0006456139,0.0005676546,0.0005791773,0.0001824327,0.0002809222,0.0002357246,0.0004515527,0.001000905],"category_scores_gemma":[0.0001191138,0.0002514604,0.0006170951,0.0002038524,0.0003088774,0.0003051254,0.0002624377,0.001129907,0.0001794732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001691333,"about_ca_system_score_gemma":0.0001888583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003506498,"about_ca_topic_score_gemma":0.001195478,"domain_scores_codex":[0.9998301,0.0000358274,0.00001979738,0.00002936107,0.00004486423,0.00004004714],"domain_scores_gemma":[0.9998379,0.00001247871,0.00005211689,0.00002075268,0.00002142411,0.00005527318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001788453,0.0003221507,0.0005097955,0.0001066979,0.00004066004,0.00004284055,0.00002740768,0.00005405755,0.9943011,0.00008066066,0.0000354949,0.002690617],"study_design_scores_gemma":[0.0002613797,0.005131291,0.02827256,0.00003216575,0.0002212174,0.0002433491,0.00008783993,0.001073931,0.9626431,0.0001370417,0.001876443,0.00001961859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994842,0.002359949,0.001573628,0.0002118418,0.00005475193,0.00002119783,0.0001580863,0.00007000827,0.0007085263],"genre_scores_gemma":[0.9927643,0.002096684,0.002372509,0.0001800938,0.00004531874,0.00006524579,0.0003283373,0.0000242045,0.002123358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001000905,"threshold_uncertainty_score":0.00334841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02548884188923163,"score_gpt":0.3257025055575184,"score_spread":0.3002136636682868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}