{"id":"W3048423346","doi":"10.1042/bst20190988","title":"The constitutive activity of the viral-encoded G protein-coupled receptor US28 supports a complex signalling network contributing to cancer development","year":2020,"lang":"en","type":"review","venue":"Biochemical Society Transactions","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University Belfast; Queen's University; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust","keywords":"Biology; Lytic cycle; Signalling; G protein-coupled receptor; Receptor; Cell biology; Human cytomegalovirus; Signal transduction; Computational biology; CCR3; Virus; Chemokine receptor; Genetics; Chemokine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006795379,0.0004380775,0.001444829,0.00002024921,0.001257447,0.00005549381,0.0003806698,0.0004259009,0.0003554861],"category_scores_gemma":[0.0001100787,0.0002577975,0.00140987,0.000909068,0.0004758359,0.0000328623,0.000105213,0.001389704,0.00002044864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000922923,"about_ca_system_score_gemma":0.003305055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001796485,"about_ca_topic_score_gemma":0.00004418672,"domain_scores_codex":[0.9969471,0.0001413611,0.0007797013,0.0005460625,0.0006796807,0.0009061669],"domain_scores_gemma":[0.9982421,0.0004427631,0.0003364288,0.0003414097,0.0002776563,0.0003596646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004509632,0.0004680845,0.00001622832,0.009830242,0.004673053,0.000006097689,0.001003356,0.0000387984,0.07363355,0.00006495055,0.008678257,0.9011364],"study_design_scores_gemma":[0.000447819,0.00004368247,0.00001001006,0.005484183,0.0006769047,0.000006412969,0.00005208988,0.0001864768,0.01396943,0.000004746762,0.9788212,0.0002971078],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001232886,0.9606463,0.02445025,0.00342141,0.0003268305,0.008967442,0.000714218,0.0001156273,0.0001250636],"genre_scores_gemma":[0.01790874,0.9756789,0.003039265,0.0002892523,0.000556967,0.001836707,0.00009115469,0.0000840055,0.0005149831],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9701429,"threshold_uncertainty_score":0.9999874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06009072149925661,"score_gpt":0.3522943278289545,"score_spread":0.2922036063296979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}