{"id":"W3048429360","doi":"10.1158/1538-7445.pedca19-b09","title":"Abstract B09: Epigenetic changes mediated by H3.3 G34R mutation in a CRISPR-edited pediatric glioblastoma cell line","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"","keywords":"Epigenome; CRISPR; Carcinogenesis; Biology; Epigenetics; Histone; Mutation; Genetics; Histone H3; Cancer research; DNA methylation; Methylation; Transcriptome; Epigenomics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001422399,0.0002461056,0.0003239781,0.0002253261,0.0002808663,0.0002681838,0.00029889,0.0003642506,0.00201636],"category_scores_gemma":[0.0001263285,0.000135602,0.0002820029,0.0002642515,0.0002159681,0.0001043752,0.0002315914,0.0007661978,0.0007840504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003855303,"about_ca_system_score_gemma":0.0003620906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004699431,"about_ca_topic_score_gemma":0.004980634,"domain_scores_codex":[0.9997912,0.00001145828,0.00001899615,0.00005638502,0.00008093921,0.00004107934],"domain_scores_gemma":[0.9998767,0.00002133907,0.00002782367,0.00001912532,0.00002242218,0.00003265281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006453317,0.00002123672,0.0005002708,0.00003662042,0.000007273599,0.00009524659,0.00003183963,0.0001429134,0.9973442,0.00009449988,0.000301866,0.001359458],"study_design_scores_gemma":[0.00001975251,0.0002092093,0.01746483,0.00001104762,0.00002682718,0.0003809464,0.00009349053,0.002478257,0.9708804,0.00007904372,0.008336696,0.00001944266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9640453,0.0007785732,0.01613144,0.0002301074,0.000117887,0.0001261372,0.01348652,0.0009379652,0.004146111],"genre_scores_gemma":[0.958863,0.0005849765,0.01528563,0.0002981028,0.00001141945,0.0002154456,0.01510796,0.0002247757,0.009408742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004699431,"threshold_uncertainty_score":0.009344161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02845150336223706,"score_gpt":0.3752640989198378,"score_spread":0.3468125955576007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}