{"id":"W3048505842","doi":"10.1007/s00401-020-02207-w","title":"Antibody against TDP-43 phosphorylated at serine 375 suggests conformational differences of TDP-43 aggregates among FTLD–TDP subtypes","year":2020,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; NOMIS Stiftung; Fondation Brain Canada; ALS Society of Canada","keywords":"Frontotemporal lobar degeneration; C9orf72; Phosphorylation; Amyotrophic lateral sclerosis; Biology; Pathological; Pathology; Immunohistochemistry; Serine; Genetics; Allele; Dementia; Medicine; Frontotemporal dementia; Immunology; Gene; Disease; Trinucleotide repeat expansion","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001950897,0.0002595742,0.0001933748,0.0004851597,0.0002692596,0.0001943197,0.0001798797,0.0002981761,0.0009659198],"category_scores_gemma":[0.0001755613,0.0001506082,0.0002168875,0.0002040276,0.0003241255,0.00016471,0.0001987201,0.0002539343,0.0002111573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002863983,"about_ca_system_score_gemma":0.0001211112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001574605,"about_ca_topic_score_gemma":0.001387416,"domain_scores_codex":[0.9998763,0.00001105413,0.00001935323,0.00003920099,0.00002576283,0.00002844786],"domain_scores_gemma":[0.9999115,0.00001589494,0.00001884428,0.00001074297,0.00001447852,0.00002855678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000205429,0.00003033017,0.01220933,0.00002757872,0.00002841664,0.0004265019,0.00007939193,0.00004673674,0.9857485,0.00005365235,0.0000428705,0.0011013],"study_design_scores_gemma":[0.00007273446,0.001259688,0.5481367,0.00002626689,0.0002063198,0.01322256,0.0005298794,0.003394794,0.4304349,0.0004278488,0.002269828,0.00001865768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991301,0.0001661483,0.0003630185,0.0000128184,0.000003147434,0.000004227708,0.00003436265,0.000009512715,0.0002767727],"genre_scores_gemma":[0.9990357,0.00008772911,0.0004965284,0.00001523996,0.000003785023,0.000004739629,0.0001509607,0.000002795504,0.0002024967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001574605,"threshold_uncertainty_score":0.003231347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0336159715366122,"score_gpt":0.2781677863743643,"score_spread":0.2445518148377522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}