{"id":"W3048507351","doi":"10.1016/j.ekir.2020.08.003","title":"Safety, Tolerability and Efficacy of Narsoplimab, a Novel MASP-2 Inhibitor for the Treatment of IgA Nephropathy","year":2020,"lang":"en","type":"article","venue":"Kidney International Reports","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Omeros Corporation","keywords":"Medicine; Tolerability; Proteinuria; Adverse effect; Dosing; Internal medicine; Renal function; Nephropathy; Urology; Gastroenterology; Endocrinology; Kidney","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001031764,0.0001044003,0.0002698549,0.00003009166,0.0000299211,0.000008033657,0.00004063636,0.00003237164,0.00005211614],"category_scores_gemma":[0.001189399,0.00006532895,0.0001920129,0.00006361739,0.0001026257,0.00003703129,0.0000279529,0.00003222863,5.335601e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004274338,"about_ca_system_score_gemma":0.0001680115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004679213,"about_ca_topic_score_gemma":0.000001137195,"domain_scores_codex":[0.9988945,0.000007514841,0.0005178639,0.0002140094,0.0002833758,0.00008278651],"domain_scores_gemma":[0.9989741,0.0001614928,0.0002675512,0.000177912,0.0002304485,0.0001884561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02483713,0.0140967,0.5042465,0.002892139,0.004479483,0.0007140157,0.01242896,0.0002753469,0.2315243,0.005077995,0.02644662,0.1729808],"study_design_scores_gemma":[0.009643956,0.004335596,0.6022881,0.0005383071,0.0008749733,0.0004803975,0.0004816441,0.004656001,0.03559628,0.000502422,0.3403222,0.0002801223],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9692274,0.001254996,0.00104155,0.02574367,0.0004177975,0.001015805,0.0004149294,0.00002635381,0.0008575395],"genre_scores_gemma":[0.9978727,0.0003591324,0.0006275524,0.0006521743,0.0002544981,0.00003555946,0.00008360599,0.000009963599,0.0001048668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3138755,"threshold_uncertainty_score":0.2664037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0234923421260726,"score_gpt":0.290370137598909,"score_spread":0.2668777954728364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}