{"id":"W3048660074","doi":"10.3389/fcimb.2020.00408","title":"LPG2 Gene Duplication in Leishmania infantum: A Case for CRISPR-Cas9 Gene Editing","year":2020,"lang":"en","type":"article","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Foundation for Scientific and Technological Development in Health; Fundação Oswaldo Cruz; Fundação de Amparo à Pesquisa do Estado da Bahia; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Lipophosphoglycan; Leishmania infantum; Biology; CRISPR; Leishmania; Gene; Virulence; Gene targeting; Gene duplication; Genetics; Leishmania donovani; Parasite hosting; Leishmaniasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004185878,0.0003818829,0.000347472,0.0002081961,0.000186792,0.0007171701,0.0004645977,0.001018095,0.0008770745],"category_scores_gemma":[0.0004848366,0.0001798731,0.0003290037,0.000134756,0.00041667,0.0002740444,0.0004067429,0.00103687,0.0002813865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003631661,"about_ca_system_score_gemma":0.000339067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005071014,"about_ca_topic_score_gemma":0.0007467064,"domain_scores_codex":[0.9997832,0.0000487075,0.00002096119,0.00005149722,0.00005309276,0.00004252102],"domain_scores_gemma":[0.9998683,0.00004087043,0.00002233557,0.00002829136,0.000015736,0.00002454717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002088541,0.00004317686,0.001007771,0.0002394677,0.00002251146,0.004111542,0.0001615387,0.000634702,0.974817,0.003542467,0.0005621312,0.01464887],"study_design_scores_gemma":[0.0000805473,0.0005192753,0.0052714,0.0001490351,0.0001429524,0.0149609,0.0003340201,0.01118921,0.8860559,0.00267299,0.07855294,0.00007077247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9064152,0.00892342,0.06479318,0.005205124,0.0003287636,0.0002082276,0.0007111596,0.001287443,0.01212745],"genre_scores_gemma":[0.9584893,0.004141684,0.0319375,0.0006104435,0.00003927525,0.0001015491,0.0005528642,0.0001248987,0.00400239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001018095,"threshold_uncertainty_score":0.002934158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02313611560159533,"score_gpt":0.2772730472263515,"score_spread":0.2541369316247562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}