{"id":"W3048660074","doi":"10.3389/fcimb.2020.00408","title":"LPG2 Gene Duplication in Leishmania infantum: A Case for CRISPR-Cas9 Gene Editing","year":2020,"lang":"en","type":"article","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Foundation for Scientific and Technological Development in Health; Fundação Oswaldo Cruz; Fundação de Amparo à Pesquisa do Estado da Bahia; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Lipophosphoglycan; Leishmania infantum; Biology; CRISPR; Leishmania; Gene; Virulence; Gene targeting; Gene duplication; Genetics; Leishmania donovani; Parasite hosting; Leishmaniasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003855604,0.0001752558,0.0004465235,0.0002951981,0.0001154752,0.00001896118,0.00004922676,0.0001994691,0.00001691196],"category_scores_gemma":[0.0003519391,0.0001742229,0.00007542635,0.0003173697,0.000140024,0.000102221,0.00008008797,0.0003112232,0.000006868544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001425634,"about_ca_system_score_gemma":0.00004980992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002617886,"about_ca_topic_score_gemma":0.0001081778,"domain_scores_codex":[0.9985919,0.0001111776,0.0004073615,0.0004702678,0.0000439182,0.0003753948],"domain_scores_gemma":[0.9994863,0.00005576807,0.00009769743,0.0001461329,0.0001082865,0.000105803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003088884,0.0001304318,0.3113439,0.0002728237,0.0000933261,0.0003958765,0.0008863459,0.0000272341,0.6638111,0.00002888224,0.01848694,0.004214209],"study_design_scores_gemma":[0.02004135,0.003449161,0.04277489,0.0001946324,0.0002779448,0.006854915,0.00219727,0.01865267,0.7251655,0.0005068409,0.1787252,0.001159664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9490927,0.002136144,0.0448048,0.00225547,0.0004946305,0.001005424,0.00003225835,0.0000445387,0.0001339771],"genre_scores_gemma":[0.9912872,0.0009606571,0.006256326,0.0006472383,0.0004335798,0.0001526749,0.0001748485,0.00002714492,0.00006030258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.268569,"threshold_uncertainty_score":0.7104604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02313611560159533,"score_gpt":0.2772730472263515,"score_spread":0.2541369316247562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}