{"id":"W3048663027","doi":"10.1002/bit.27531","title":"Online/at‐line measurement, analysis and control of product titer and critical product quality attributes (CQAs) during process development","year":2020,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Advanced Micro Devices (Canada)","funders":"","keywords":"Critical quality attributes; Quality by Design; Process analytical technology; Process engineering; Bioprocess; Process validation; Computer science; Process (computing); Quality (philosophy); Process capability; Downstream (manufacturing); Work in process; Engineering; Operations management","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002500335,0.0008272585,0.0006461932,0.0008622437,0.000460967,0.001843974,0.001076108,0.0005343655,0.0008308906],"category_scores_gemma":[0.002475603,0.0003657131,0.0003508391,0.0007588801,0.0008362309,0.001377031,0.0009274583,0.001342013,0.0006076252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007813665,"about_ca_system_score_gemma":0.001418542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008882729,"about_ca_topic_score_gemma":0.001142472,"domain_scores_codex":[0.9966193,0.0004869831,0.0002032444,0.0008312628,0.001698065,0.0001609798],"domain_scores_gemma":[0.9977797,0.0007043405,0.0005424406,0.000313591,0.0005510232,0.0001089989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001381001,0.00009514711,0.002396597,0.0001202934,0.00001778599,0.00005687527,0.0000971754,0.0004825798,0.9607747,0.0007101488,0.0004572954,0.03465333],"study_design_scores_gemma":[0.00001252918,0.0001982826,0.002752879,0.00001123849,0.00002172839,0.0001024446,0.00002558433,0.008085473,0.9849377,0.0003357237,0.003490287,0.00002613476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.2778811,0.00211215,0.7083991,0.000415456,0.0002217361,0.0006139801,0.001260492,0.005045894,0.004050075],"genre_scores_gemma":[0.6251765,0.002123679,0.3662256,0.0006923469,0.0001382698,0.0006202965,0.001029602,0.0004727011,0.003520974],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.002500335,"threshold_uncertainty_score":0.01322323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02295770423491006,"score_gpt":0.2728364798332205,"score_spread":0.2498787755983104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}