{"id":"W3048700252","doi":"10.1371/journal.ppat.1008835","title":"Downy Mildew effector HaRxL21 interacts with the transcriptional repressor TOPLESS to promote pathogen susceptibility","year":2020,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Plant-Microbe Interactions and Immunity","field":"Agricultural and Biological Sciences","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; Deutscher Akademischer Austauschdienst; Deutsche Forschungsgemeinschaft; York University; James Hutton Institute; Ohio State University","keywords":"Effector; Oomycete; Arabidopsis; Biology; Repressor; Downy mildew; Virulence; Cell biology; Pathogen; Genetics; Transcription factor; Mutant; Gene; Botany","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001743391,0.0002045201,0.0002266071,0.000008330925,0.0003258893,0.0001160353,0.0004120287,0.00006414048,0.0008335966],"category_scores_gemma":[0.0001192401,0.00006607771,0.0001306435,0.0002982095,0.00005084425,0.0001470788,0.00008906514,0.0002796047,0.0002340894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003033334,"about_ca_system_score_gemma":0.00001319429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009000802,"about_ca_topic_score_gemma":0.0006201251,"domain_scores_codex":[0.9986051,0.0002001812,0.0002163302,0.000442061,0.0002299528,0.0003063977],"domain_scores_gemma":[0.999256,0.0001910723,0.00007504931,0.000145363,0.000123832,0.0002087353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002039065,0.0001829475,0.001997016,0.0000141705,0.0000360648,0.00001552723,0.0009912349,0.000007482739,0.9905827,0.000006953951,0.0007926199,0.005169372],"study_design_scores_gemma":[0.0005414332,0.002352243,0.5008447,0.0002221547,0.0001666083,0.00008472679,0.001351219,0.0003081424,0.3367063,0.00002506775,0.1565487,0.0008486278],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886433,0.00004505475,0.00002657746,0.008713139,0.0000767577,0.0006621311,0.001474753,0.00008855943,0.0002696596],"genre_scores_gemma":[0.9972141,0.000008799284,0.0002162377,0.001872827,0.0002559451,0.00006856472,0.0002210069,0.000002563392,0.0001399291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6538764,"threshold_uncertainty_score":0.9127298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03274701328615916,"score_gpt":0.2173988144165304,"score_spread":0.1846518011303712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}