{"id":"W3048730325","doi":"10.1136/jitc-2020-000981","title":"Enhanced immunotherapeutic profile of oncolytic virus-based cancer vaccination using cyclophosphamide preconditioning","year":2020,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; McMaster University","funders":"Terry Fox Foundation; Seerave Foundation; Ontario Institute for Cancer Research","keywords":"Medicine; Oncolytic virus; Immunology; Antigen; Vaccination; CD8; Melanoma; Cytotoxic T cell; Cancer; Cancer research; Cancer immunotherapy; Cyclophosphamide; Immunotherapy; Virus; Immune system; Chemotherapy; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001070653,0.0002972823,0.0001765898,0.0001130806,0.00005529528,0.000162453,0.0001222283,0.0002098873,0.0006308937],"category_scores_gemma":[0.00007756162,0.00007045131,0.0001088988,0.00009252386,0.0001363399,0.000143272,0.00009509917,0.0004344735,0.0001109592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001263108,"about_ca_system_score_gemma":0.0001382363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003218993,"about_ca_topic_score_gemma":0.0004963368,"domain_scores_codex":[0.999947,0.00001001259,0.00000341231,0.00001015875,0.00001004959,0.00001934476],"domain_scores_gemma":[0.9999682,0.000006657574,0.00000785177,0.000004087784,0.000003931803,0.000009267186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002814741,0.0001480624,0.00009939777,0.00003528616,0.000003008875,0.0000217677,0.00001201488,0.0002763989,0.9963163,0.00004493284,0.00002811952,0.002733188],"study_design_scores_gemma":[0.0000744975,0.007601604,0.002714241,0.000008111787,0.00002670792,0.0001363286,0.000007980917,0.00142759,0.9869618,0.00002658749,0.001010296,0.000004240416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974949,0.0006812873,0.001005508,0.000025064,0.00002039014,0.00007567812,0.00008284014,0.00003430972,0.0005800319],"genre_scores_gemma":[0.9979862,0.0004936563,0.000837168,0.00001709412,0.000007952385,0.00004197695,0.0001122732,0.000005507695,0.0004981263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006308937,"threshold_uncertainty_score":0.002110541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02971183324604781,"score_gpt":0.3355940651898143,"score_spread":0.3058822319437665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}