{"id":"W3048730325","doi":"10.1136/jitc-2020-000981","title":"Enhanced immunotherapeutic profile of oncolytic virus-based cancer vaccination using cyclophosphamide preconditioning","year":2020,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; McMaster University","funders":"Terry Fox Foundation; Seerave Foundation; Ontario Institute for Cancer Research","keywords":"Medicine; Oncolytic virus; Immunology; Antigen; Vaccination; CD8; Melanoma; Cytotoxic T cell; Cancer; Cancer research; Cancer immunotherapy; Cyclophosphamide; Immunotherapy; Virus; Immune system; Chemotherapy; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004402766,0.0003490079,0.000816154,0.0002291254,0.0003888097,0.00003247991,0.0004630268,0.0002719172,0.005218151],"category_scores_gemma":[0.00007200362,0.0003187966,0.0005300916,0.0003752283,0.0001773737,0.0003310969,0.00001977572,0.0004220406,0.000007057894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002571999,"about_ca_system_score_gemma":0.0009296009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003673444,"about_ca_topic_score_gemma":0.00001731093,"domain_scores_codex":[0.9976506,0.0002492271,0.001203865,0.0002874494,0.00014033,0.000468476],"domain_scores_gemma":[0.9972215,0.0003185826,0.001599384,0.0002589581,0.0005688948,0.00003262469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01026042,0.0001751211,0.000286408,0.0001563735,0.001290407,3.33305e-7,0.001564206,0.003025178,0.8995377,0.00004468441,0.0001935718,0.08346555],"study_design_scores_gemma":[0.00806234,0.00116776,0.004142268,0.0004369714,0.000161905,0.00001087161,0.0002088078,0.0004074026,0.9673557,0.0000870155,0.0176189,0.0003400061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.853371,0.1272554,0.01565272,0.0004995788,0.001832069,0.001006318,0.000261302,0.00004428552,0.00007731031],"genre_scores_gemma":[0.9896348,0.007443202,0.0008825796,0.0009088999,0.0001278725,0.0001962369,0.0000305763,0.0001006693,0.0006752231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1362637,"threshold_uncertainty_score":0.9999264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02971183324604781,"score_gpt":0.3355940651898143,"score_spread":0.3058822319437665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}