{"id":"W3048783046","doi":"10.3389/fnagi.2020.00230","title":"Rapamycin, by Inhibiting mTORC1 Signaling, Prevents the Loss of Striatal Bidirectional Synaptic Plasticity in a Rat Model of L-DOPA-Induced Dyskinesia","year":2020,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministero dell’Istruzione, dell’Università e della Ricerca; School of Medicine, New York University; Ministero della Salute; York University","keywords":"mTORC1; Synaptic plasticity; Neuroscience; Dyskinesia; Plasticity; Neuroplasticity; Chemistry; PI3K/AKT/mTOR pathway; Psychology; Signal transduction; Biology; Parkinson's disease; Cell biology; Medicine; Receptor; Internal medicine; Materials science; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003023438,0.001417171,0.001214249,0.0009369713,0.0003661514,0.000349734,0.0006366028,0.0008344654,0.002240844],"category_scores_gemma":[0.0001410036,0.0004422556,0.0008218439,0.0003665677,0.0005782937,0.000490007,0.000286809,0.002476227,0.0008069694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004901418,"about_ca_system_score_gemma":0.0007520054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002194233,"about_ca_topic_score_gemma":0.003717727,"domain_scores_codex":[0.9997063,0.00004200481,0.00004206153,0.00005657672,0.00005930331,0.00009365352],"domain_scores_gemma":[0.9998032,0.00001074958,0.00005471618,0.00002143011,0.00002240358,0.0000875087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003582403,0.001527049,0.0003726483,0.0002800555,0.00008605129,0.0003010826,0.00006393813,0.0003211856,0.9855524,0.0003948778,0.0007821915,0.00673618],"study_design_scores_gemma":[0.0008182147,0.01552561,0.009595509,0.00009849427,0.0002578721,0.0009165161,0.0001964723,0.004592177,0.9601194,0.0003780341,0.007446091,0.00005556436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855488,0.005268313,0.002599409,0.0009143779,0.0004196876,0.0001673031,0.001704323,0.0007803402,0.002597408],"genre_scores_gemma":[0.9823048,0.004847303,0.003100341,0.0002108141,0.00006066301,0.0004564489,0.001637763,0.00006749279,0.007314363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002240844,"threshold_uncertainty_score":0.007496357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05452730792602003,"score_gpt":0.3028425749146434,"score_spread":0.2483152669886234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}