{"id":"W3048783046","doi":"10.3389/fnagi.2020.00230","title":"Rapamycin, by Inhibiting mTORC1 Signaling, Prevents the Loss of Striatal Bidirectional Synaptic Plasticity in a Rat Model of L-DOPA-Induced Dyskinesia","year":2020,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministero dell’Istruzione, dell’Università e della Ricerca; School of Medicine, New York University; Ministero della Salute; York University","keywords":"mTORC1; Synaptic plasticity; Neuroscience; Dyskinesia; Plasticity; Neuroplasticity; Chemistry; PI3K/AKT/mTOR pathway; Psychology; Signal transduction; Biology; Parkinson's disease; Cell biology; Medicine; Receptor; Internal medicine; Materials science; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005473353,0.0002539675,0.0004162786,0.000368494,0.0002077062,0.00004864671,0.001300533,0.00005364522,0.000005197236],"category_scores_gemma":[0.002653266,0.0002095584,0.0001037557,0.002770554,0.001024714,0.0004994057,0.0003619638,0.0007244397,0.00000126501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000672585,"about_ca_system_score_gemma":0.0003106384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002207516,"about_ca_topic_score_gemma":0.000001222938,"domain_scores_codex":[0.9960868,0.0005841003,0.0006673395,0.001021642,0.0009624567,0.0006776457],"domain_scores_gemma":[0.9987586,0.0005017341,0.0003322044,0.0001935861,0.00004848552,0.0001654541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001342916,0.0001533302,0.01895387,0.00003615782,8.874559e-7,0.00005696751,0.000306598,0.0271667,0.9527627,0.00001993749,0.0003005265,0.0001079915],"study_design_scores_gemma":[0.0005971108,0.0001788644,0.0003454083,0.00003796432,0.000004755983,0.00001224814,0.00003789188,0.277762,0.7208338,0.00005851288,0.00000740284,0.0001240726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947617,0.0000212924,0.003562743,0.0004621174,0.0006044207,0.0004866355,0.00004435825,0.00003362042,0.0000231081],"genre_scores_gemma":[0.9988535,0.00005333178,0.00007155873,0.0009131207,0.00002816503,0.00002503857,3.456465e-7,0.00002160466,0.00003332565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2505953,"threshold_uncertainty_score":0.8545543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05452730792602003,"score_gpt":0.3028425749146434,"score_spread":0.2483152669886234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}