{"id":"W3048795992","doi":"10.3390/toxins12080511","title":"Safety, Tolerability, Pharmacokinetics, and Concentration-QTc Analysis of Tetrodotoxin: A Randomized, Dose Escalation Study in Healthy Adults","year":2020,"lang":"en","type":"article","venue":"Toxins","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Celerion (Canada); Inimex Pharmaceuticals (Canada)","funders":"","keywords":"Medicine; Tolerability; Placebo; QT interval; Anesthesia; Cmax; Sodium channel blocker; Bioequivalence; Pharmacokinetics; Adverse effect; Crossover study; myalgia; Pharmacodynamics; Sodium channel; Pharmacology; Internal medicine; Sodium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002448137,0.001202144,0.00225076,0.0003968412,0.0004463871,0.0005402329,0.0005376296,0.001117484,0.002421571],"category_scores_gemma":[0.00208128,0.000595257,0.001245982,0.0003699132,0.001054231,0.0006332395,0.0003726043,0.001586997,0.0004865505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003920235,"about_ca_system_score_gemma":0.0007405109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004150441,"about_ca_topic_score_gemma":0.0007507331,"domain_scores_codex":[0.9985037,0.0007162488,0.0001234708,0.0002887787,0.0001746663,0.0001932862],"domain_scores_gemma":[0.9984751,0.0002884987,0.0004333965,0.0002249712,0.0001810907,0.0003970286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8744904,0.05510922,0.006678402,0.0003313275,0.0009924044,0.0001290073,0.00021612,0.0005684209,0.03567283,0.00007141003,0.0005517732,0.02518868],"study_design_scores_gemma":[0.2431841,0.7344939,0.01804148,0.00001029882,0.0004876074,0.00008237032,0.00003534001,0.0005043391,0.002462495,0.00006615372,0.0006075567,0.00002433341],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962122,0.0004820667,0.0007257125,0.00007467819,0.00005331159,0.001895261,0.0002552505,0.00003906092,0.0002625027],"genre_scores_gemma":[0.9932707,0.0005126382,0.001774902,0.0003527907,0.0001698058,0.002465747,0.0004280337,0.00001878417,0.001006601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002448137,"threshold_uncertainty_score":0.01294714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01592696945858559,"score_gpt":0.2832232801236292,"score_spread":0.2672963106650437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}