{"id":"W3048795992","doi":"10.3390/toxins12080511","title":"Safety, Tolerability, Pharmacokinetics, and Concentration-QTc Analysis of Tetrodotoxin: A Randomized, Dose Escalation Study in Healthy Adults","year":2020,"lang":"en","type":"article","venue":"Toxins","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Celerion (Canada); Inimex Pharmaceuticals (Canada)","funders":"","keywords":"Medicine; Tolerability; Placebo; QT interval; Anesthesia; Cmax; Sodium channel blocker; Bioequivalence; Pharmacokinetics; Adverse effect; Crossover study; myalgia; Pharmacodynamics; Sodium channel; Pharmacology; Internal medicine; Sodium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003093222,0.0001015461,0.000338398,0.00007180156,0.00003119612,0.000009845268,0.00005115299,0.00006390228,0.00006425333],"category_scores_gemma":[0.0001715339,0.00009539717,0.00008953978,0.0003758061,0.00006281683,0.000005940533,0.00003918139,0.00005634749,0.000001146295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001428974,"about_ca_system_score_gemma":0.00003580304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000588242,"about_ca_topic_score_gemma":0.0001527515,"domain_scores_codex":[0.9988278,0.0002027699,0.0004388407,0.0002914458,0.0001331937,0.0001059184],"domain_scores_gemma":[0.9995461,0.00003767458,0.0001255575,0.0001225834,0.00008611975,0.00008202605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.4427938,0.002383648,0.3919702,0.000208186,0.002034045,0.000005239969,0.01119125,0.04825263,0.08672527,0.0004493381,0.0004282921,0.01355816],"study_design_scores_gemma":[0.277566,0.003960226,0.2981292,0.0000239636,0.001021634,0.000001856026,0.002043477,0.3972346,0.01775586,0.00004306787,0.001623184,0.0005969565],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953189,0.0001486615,0.002552283,0.0008780477,0.00009108273,0.0007589424,0.00002110363,0.000008876224,0.0002221093],"genre_scores_gemma":[0.9990912,0.0001371688,0.0000706895,0.0003643929,0.0001188444,0.00002024221,0.0001735867,0.000006861913,0.00001702494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.348982,"threshold_uncertainty_score":0.3890184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01592696945858559,"score_gpt":0.2832232801236292,"score_spread":0.2672963106650437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}