{"id":"W3048837274","doi":"10.1111/bph.15223","title":"Pharmacological properties of TRPM3 isoforms are determined by the length of the pore loop","year":2020,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Fondation Médicale Reine Elisabeth; Fondation contre le Cancer; Fonds Wetenschappelijk Onderzoek; Stichting Tegen Kanker; Vancouver Coastal Health Research Institute; Queen Elisabeth Medical Foundation; Universität des Saarlandes; Michael Smith Health Research BC; Vlaamse regering; KU Leuven; Belgische Federale Overheidsdiensten; Australian Government","keywords":"Biophysics; Transient receptor potential channel; Gating; Chemistry; Alternative splicing; Gene isoform; Mutagenesis; Receptor; Mutant; Biochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002490902,0.0002416386,0.0002406009,0.0001378339,0.000180968,0.0004333106,0.0002945965,0.0003717841,0.001348248],"category_scores_gemma":[0.0006620507,0.00009835643,0.000369425,0.0001527851,0.000438672,0.0004134235,0.0002595541,0.00060363,0.000477546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000256215,"about_ca_system_score_gemma":0.0001256237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001566498,"about_ca_topic_score_gemma":0.00013544,"domain_scores_codex":[0.9997259,0.00003636678,0.00003369307,0.0000599596,0.00009386002,0.00005018133],"domain_scores_gemma":[0.9995193,0.0001261921,0.0001764023,0.00005190305,0.00005082853,0.00007532213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001773305,0.000008861181,0.0004864129,0.00002223545,0.000005303387,0.00004504003,0.0000135814,0.00005885829,0.9984549,0.00006845382,0.00001459654,0.0006443183],"study_design_scores_gemma":[0.00003482596,0.000281964,0.01509265,0.00001169455,0.00005356395,0.001566048,0.00007512635,0.001377417,0.9792309,0.0002184289,0.002042256,0.0000151666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949582,0.0006384438,0.003420387,0.00007145545,0.0000198863,0.00001673639,0.0002964315,0.00004610365,0.0005323433],"genre_scores_gemma":[0.9977974,0.0002698488,0.001318248,0.00003434884,0.00000826165,0.00002014798,0.0002823771,0.00002419911,0.0002452198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001348248,"threshold_uncertainty_score":0.004510343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05475522421049656,"score_gpt":0.2761000178348749,"score_spread":0.2213447936243784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}