{"id":"W3048862743","doi":"10.3389/fgene.2020.00885","title":"Neurodevelopmental Disorders Caused by Defective Chromatin Remodeling: Phenotypic Complexity Is Highlighted by a Review of ATRX Function","year":2020,"lang":"en","type":"review","venue":"Frontiers in Genetics","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian Institutes of Health Research","keywords":"ATRX; Chromatin remodeling; Phenotype; Chromatin; Function (biology); Biology; Computational biology; Genetics; Epigenetics; Neuroscience; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004202746,0.0006687558,0.0009846381,0.001965668,0.0001824063,0.0006421945,0.0004722119,0.0006887554,0.002481886],"category_scores_gemma":[0.0006060468,0.0001716981,0.0003326093,0.001832095,0.0003745597,0.0008989234,0.00056955,0.001160944,0.001467476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003908262,"about_ca_system_score_gemma":0.0007344605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006590858,"about_ca_topic_score_gemma":0.001167254,"domain_scores_codex":[0.9998685,0.00002317813,0.00002418763,0.00003072153,0.00003994573,0.00001345184],"domain_scores_gemma":[0.9996706,0.0001725649,0.00004185799,0.000008920176,0.00007597262,0.00003007859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005635684,0.00002501989,0.0003009589,0.0111911,0.0000744234,0.0002823077,0.00006144701,0.0002212948,0.002454564,0.003412363,0.03026079,0.9516594],"study_design_scores_gemma":[0.000006017148,0.00007340166,0.00126633,0.002539169,0.0001007346,0.002807465,0.0000489106,0.00004999848,0.0004809144,0.001478835,0.9911321,0.00001613442],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009542279,0.9987615,0.0001211214,0.0002518964,0.0001854093,0.000001340511,0.00001760365,0.000006805958,0.0005588861],"genre_scores_gemma":[0.0006213664,0.9984285,0.0001739053,0.0001893336,0.0002007713,0.00000232192,0.00003437555,0.000001852116,0.0003475726],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002481886,"threshold_uncertainty_score":0.008302689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01886913680180308,"score_gpt":0.2732839301328466,"score_spread":0.2544147933310436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}