{"id":"W3048862743","doi":"10.3389/fgene.2020.00885","title":"Neurodevelopmental Disorders Caused by Defective Chromatin Remodeling: Phenotypic Complexity Is Highlighted by a Review of ATRX Function","year":2020,"lang":"en","type":"review","venue":"Frontiers in Genetics","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian Institutes of Health Research","keywords":"ATRX; Chromatin remodeling; Phenotype; Chromatin; Function (biology); Biology; Computational biology; Genetics; Epigenetics; Neuroscience; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001786044,0.0005804392,0.001498689,0.00007610383,0.00006327182,0.00001497829,0.0004226455,0.0004330643,0.00002632281],"category_scores_gemma":[0.00005730851,0.0005788655,0.0004273459,0.0003784517,0.0001423878,0.000003623559,0.0001741405,0.0003231718,0.000005362142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001590675,"about_ca_system_score_gemma":0.0004022467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002050059,"about_ca_topic_score_gemma":0.000008154809,"domain_scores_codex":[0.9971761,0.0002639156,0.001039107,0.0008613098,0.0003136798,0.0003459399],"domain_scores_gemma":[0.998661,0.00001256094,0.0005998785,0.0005219258,0.00008634304,0.0001183296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000286004,0.0001037932,0.0000488898,0.03364739,0.0003592825,6.875553e-7,0.00005671069,0.00001305935,0.0005197162,0.0000011384,0.3289698,0.6362509],"study_design_scores_gemma":[0.0004377394,0.0001944275,0.000008113331,0.01009281,0.000498402,0.000002882223,0.00001938531,0.0006560996,0.0002664112,0.00006151105,0.9871777,0.0005845074],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001732481,0.9821284,0.01530432,0.0000660303,0.0005794582,0.001018112,0.0005430641,0.00002181634,0.0001655906],"genre_scores_gemma":[0.000115098,0.9914879,0.004903835,0.0004549984,0.00008922957,0.00008178595,0.002657906,0.0001057269,0.0001035603],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6582079,"threshold_uncertainty_score":0.9996663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01886913680180308,"score_gpt":0.2732839301328466,"score_spread":0.2544147933310436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}