{"id":"W3048886060","doi":"10.1182/bloodadvances.2020002142","title":"Gene therapy for hemophilia: anticipating the unexpected","year":2020,"lang":"en","type":"article","venue":"Blood Advances","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Hemophilia Society","funders":"","keywords":"Genetic enhancement; Medicine; Gene; Bioinformatics; Internal medicine; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004291774,0.0003479225,0.0007785351,0.0006426674,0.0003071729,0.001617783,0.0006171641,0.001795037,0.003244066],"category_scores_gemma":[0.004683075,0.0001509705,0.0003935544,0.0004627125,0.001219781,0.003194812,0.0006267958,0.003801997,0.001914285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007922454,"about_ca_system_score_gemma":0.002000196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006835955,"about_ca_topic_score_gemma":0.001507427,"domain_scores_codex":[0.9986567,0.0004899899,0.0001324863,0.0001076376,0.0005264091,0.00008669324],"domain_scores_gemma":[0.9969606,0.001405578,0.0002344736,0.000123528,0.001051533,0.0002241929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0002440773,0.00008146979,0.0003955231,0.005878189,0.00007349331,0.0003317828,0.0003958246,0.0002675932,0.007292298,0.04095437,0.1940721,0.7500134],"study_design_scores_gemma":[0.0000236007,0.0001527379,0.0002472574,0.001307727,0.00003091886,0.0004855032,0.00009723583,0.00007391382,0.0007489165,0.007230152,0.9895906,0.00001144001],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.001055965,0.9486662,0.002268638,0.03527705,0.007237879,0.00002450116,0.00006019964,0.00007139856,0.00533811],"genre_scores_gemma":[0.007466013,0.9587476,0.002336032,0.02009766,0.003900002,0.00004207562,0.0001072734,0.00005800231,0.007245333],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.004291774,"threshold_uncertainty_score":0.02269733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06063301568724029,"score_gpt":0.3500854237502413,"score_spread":0.289452408063001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}