{"id":"W3048887410","doi":"10.1080/24745332.2020.1777598","title":"Gefapixant, a P2X3 receptor antagonist, for the treatment of refractory or unexplained chronic cough: A randomized, double-blind, controlled, parallel-group, Phase 2b trial: Discussions from a Twitter journal club @respandsleepjc (#rsjc)","year":2020,"lang":"en","type":"article","venue":"Canadian Journal of Respiratory Critical Care and Sleep Medicine","topic":"Respiratory and Cough-Related Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto; St. Michael's Hospital","funders":"","keywords":"Chronic cough; Medicine; Refractory (planetary science); Antagonist; Chronic bronchitis; Club; Double blind; Asthma; Internal medicine; Gastroenterology; Randomized controlled trial; Physical therapy; Alternative medicine; Receptor; Pathology; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001813839,0.00181589,0.002533485,0.0004410818,0.0004953813,0.0008787288,0.0008279206,0.002356357,0.011182],"category_scores_gemma":[0.001231611,0.0005053609,0.002067055,0.0004645348,0.0007987246,0.00103128,0.0002947727,0.002641691,0.001552925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005891979,"about_ca_system_score_gemma":0.0009771005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001087076,"about_ca_topic_score_gemma":0.003272024,"domain_scores_codex":[0.9995868,0.0002096859,0.00003369963,0.00006158045,0.00003931947,0.00006890563],"domain_scores_gemma":[0.9996301,0.0001062007,0.0000818741,0.00002494187,0.00002803666,0.0001288832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9432092,0.006562255,0.0004365757,0.002565242,0.001555239,0.00008498297,0.00005966596,0.0003242321,0.003165238,0.0002297987,0.004532702,0.0372748],"study_design_scores_gemma":[0.9767146,0.02070135,0.0007565743,0.00005436706,0.0002992667,0.00003483333,0.00001264689,0.0001697142,0.0001686697,0.00009719708,0.0009791472,0.00001158973],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.894271,0.06143746,0.002284939,0.008143695,0.004327079,0.01361847,0.005614894,0.0006335152,0.009669014],"genre_scores_gemma":[0.918361,0.03339409,0.004774292,0.007503862,0.002979946,0.01706877,0.003796496,0.0001049282,0.01201663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.011182,"threshold_uncertainty_score":0.03740758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1191379527922278,"score_gpt":0.3949722173961735,"score_spread":0.2758342646039457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}