{"id":"W3048895920","doi":"10.1007/s12272-020-01255-w","title":"Setosphapyrone C and D accelerate macrophages cholesterol efflux by promoting LXRα/ABCA1 pathway","year":2020,"lang":"en","type":"article","venue":"Archives of Pharmacal Research","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Natural Science Foundation of China","keywords":"ABCG1; ABCA1; Liver X receptor; Scavenger receptor; Cytotoxicity; Efflux; Cholesterol; Chemistry; ATP-binding cassette transporter; Agonist; Reverse cholesterol transport; Transporter; Lipoprotein; Biochemistry; Pharmacology; Receptor; In vitro; Nuclear receptor; Biology; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007891267,0.0002231129,0.0004924464,0.000149853,0.0001580178,0.00005909164,0.0002861786,0.00006431074,0.0001906359],"category_scores_gemma":[0.0006336634,0.0001846995,0.0001015684,0.0003298337,0.0005471041,0.0001566535,0.000443332,0.001112501,0.00004495392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001040254,"about_ca_system_score_gemma":0.0001138733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003621885,"about_ca_topic_score_gemma":7.208357e-7,"domain_scores_codex":[0.997089,0.0004595879,0.0004470598,0.0005602448,0.0007659147,0.0006781598],"domain_scores_gemma":[0.9980922,0.0005607515,0.00008235509,0.0002341896,0.0001203241,0.0009101749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004887726,0.0001853281,0.005805994,0.0006316595,0.00007134047,0.00002394013,0.003107059,7.464963e-7,0.8169304,0.00003630232,0.0019563,0.1707621],"study_design_scores_gemma":[0.00664697,0.0008223623,0.02850176,0.0002351154,0.0000506993,0.00003867093,0.0002891676,0.004704788,0.9053654,0.0001109803,0.05301458,0.0002195066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843377,0.001984665,0.00006888241,0.01008967,0.00005326762,0.000781149,0.00008124999,0.00005819443,0.002545231],"genre_scores_gemma":[0.9956411,0.001115234,0.0003372105,0.001541485,0.000515411,0.00003918542,0.00003544962,0.00004879568,0.0007261822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1705426,"threshold_uncertainty_score":0.7531828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08256651226396287,"score_gpt":0.3790690310990192,"score_spread":0.2965025188350563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}