{"id":"W3048905405","doi":"10.1007/s10549-020-05782-4","title":"Treatment effect of palbociclib plus endocrine therapy by prognostic and intrinsic subtype and biomarker analysis in patients with bone-only disease: a joint analysis of PALOMA-2 and PALOMA-3 clinical trials","year":2020,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Pfizer","keywords":"Palbociclib; Internal medicine; Oncology; Medicine; Breast cancer; Hazard ratio; Progression-free survival; Placebo; Population; Biomarker; Cancer; Gastroenterology; Metastatic breast cancer; Confidence interval; Biology; Chemotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01496074,0.0006938715,0.00234773,0.0006377447,0.0001953829,0.00112765,0.0007029357,0.0004832254,0.001373119],"category_scores_gemma":[0.0106356,0.0002968436,0.006629763,0.0009602444,0.0003521697,0.0007366082,0.0005899005,0.001134061,0.000126354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005219869,"about_ca_system_score_gemma":0.0008369571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000482757,"about_ca_topic_score_gemma":0.001644704,"domain_scores_codex":[0.9942022,0.004345336,0.0004127141,0.0003689617,0.0005145523,0.0001562325],"domain_scores_gemma":[0.9895427,0.006348071,0.002385884,0.0007713686,0.0005601864,0.0003916778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.5016382,0.0009000903,0.2589286,0.003786111,0.1143498,0.0001805703,0.0001826145,0.003478973,0.00542664,0.0003875052,0.00144853,0.1092925],"study_design_scores_gemma":[0.09860607,0.07897071,0.6855663,0.0004365991,0.1144808,0.0008526043,0.000213372,0.01102416,0.002589471,0.001182252,0.005954848,0.000122711],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972769,0.02201366,0.001768198,0.0002643763,0.00006139859,0.0005157711,0.001300545,0.00006004451,0.001247104],"genre_scores_gemma":[0.9965364,0.001330719,0.0006398392,0.0001678647,0.00006068863,0.000206364,0.0007766381,0.00001267134,0.000268766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01496074,"threshold_uncertainty_score":0.07912087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09056274542627094,"score_gpt":0.4249490110503013,"score_spread":0.3343862656240304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}