{"id":"W3048912355","doi":"10.3390/m1151","title":"Phenethyl Esters and Amide of Ferulic Acid, Hydroferulic Acid, Homovanillic Acid, and Vanillic Acid: Synthesis, Free Radicals Scavenging Activity, and Molecular Modeling as Potential Cholinesterases Inhibitors","year":2020,"lang":"en","type":"article","venue":"Molbank","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Moncton","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Butyrylcholinesterase; Ferulic acid; Vanillic acid; Acetylcholinesterase; ADME; Homovanillic acid; Biochemistry; Organic chemistry; Enzyme; Aché; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000980359,0.0003347081,0.0002774788,0.0001820039,0.00007648122,0.0001941496,0.0002746093,0.0002285862,0.0008917311],"category_scores_gemma":[0.00009255069,0.0001409595,0.0002931609,0.0001670722,0.00008725236,0.0002240999,0.0001240189,0.0003007213,0.0002094587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00016716,"about_ca_system_score_gemma":0.00017821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008263308,"about_ca_topic_score_gemma":0.0009380681,"domain_scores_codex":[0.9999757,0.000004758098,0.000001273591,0.000004543223,0.000006638084,0.000007020809],"domain_scores_gemma":[0.9999784,0.000004040055,0.000008903143,0.000001422229,0.000002408701,0.000004791772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007660849,0.000315505,0.0007620531,0.0006943995,0.00009342138,0.000677872,0.00005396481,0.04748444,0.9088609,0.003537398,0.0002996483,0.03645442],"study_design_scores_gemma":[0.0003293199,0.005360591,0.002717683,0.0000652618,0.0002238597,0.0005937377,0.0000873576,0.117616,0.8483868,0.001203152,0.02335115,0.00006519288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731386,0.01248655,0.01033815,0.0001403146,0.00003609589,0.00007307659,0.000259073,0.00006169373,0.003466496],"genre_scores_gemma":[0.9793611,0.008584907,0.009603621,0.00002937777,0.00001509693,0.00004512506,0.0002238013,0.00000986731,0.00212705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008917311,"threshold_uncertainty_score":0.002983212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01654076625987675,"score_gpt":0.2522274232264334,"score_spread":0.2356866569665566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}