{"id":"W3048913754","doi":"10.1158/1538-7445.pedca19-a30","title":"Abstract A30: Alisertib acts synergistically with sonidegib by modulating primary cilia assembly in a pediatric RELA ependymoma cell line","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Smoothened; Cilium; Ciliogenesis; GLI1; Cyclopamine; Hedgehog signaling pathway; GLI2; Biology; Cancer research; Cell biology; Signal transduction","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001121071,0.0003364513,0.000500082,0.0002769943,0.000167326,0.0002124362,0.000220091,0.0002932588,0.004075217],"category_scores_gemma":[0.00008366468,0.0001020153,0.0003098522,0.000201622,0.0001310428,0.0001419018,0.0001665919,0.0005878556,0.0008051374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002131721,"about_ca_system_score_gemma":0.0003061254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009865777,"about_ca_topic_score_gemma":0.002099051,"domain_scores_codex":[0.9998915,0.00001481821,0.0000140894,0.00001678999,0.00003774815,0.00002500899],"domain_scores_gemma":[0.9999387,0.00001237477,0.000008926671,0.000006515675,0.00001161333,0.00002189934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001186336,0.0004697082,0.0007417365,0.0002805879,0.00003259961,0.0003054823,0.00005475158,0.0002402904,0.9815058,0.0001141667,0.001363093,0.01370543],"study_design_scores_gemma":[0.0002534755,0.00503386,0.01359857,0.000023439,0.00009310713,0.001040139,0.00009519638,0.001706123,0.9673205,0.00005231062,0.01076944,0.00001390733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989369,0.002700271,0.0008225468,0.0002375234,0.0001100357,0.0001163769,0.001130291,0.0002344657,0.005279297],"genre_scores_gemma":[0.9881741,0.001593487,0.00181543,0.0001495113,0.00003483423,0.0001511826,0.002072444,0.00002137563,0.005987607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004075217,"threshold_uncertainty_score":0.01363301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05756154453365862,"score_gpt":0.3402292569346398,"score_spread":0.2826677124009812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}