{"id":"W3048913754","doi":"10.1158/1538-7445.pedca19-a30","title":"Abstract A30: Alisertib acts synergistically with sonidegib by modulating primary cilia assembly in a pediatric RELA ependymoma cell line","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Smoothened; Cilium; Ciliogenesis; GLI1; Cyclopamine; Hedgehog signaling pathway; GLI2; Biology; Cancer research; Cell biology; Signal transduction","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006310934,0.0002199542,0.0002692177,0.00007942136,0.0001411934,0.00005786355,0.0003765052,0.0001837996,0.00002728892],"category_scores_gemma":[0.0005406152,0.0001963506,0.00005271977,0.0004841759,0.0001257749,0.000009379551,0.0002949084,0.000582735,0.00002415088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001015906,"about_ca_system_score_gemma":0.0006460605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001807525,"about_ca_topic_score_gemma":0.0001625528,"domain_scores_codex":[0.9975069,0.0001406206,0.0003271541,0.0007177835,0.0005868403,0.0007206681],"domain_scores_gemma":[0.9989169,0.0001149152,0.00007678249,0.0003134583,0.0002993403,0.0002786425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004113621,0.0001018709,0.006039398,0.0003585883,0.00003253564,0.0001771337,0.0002207436,0.001308821,0.9844568,0.000007668088,0.006182732,0.0007023157],"study_design_scores_gemma":[0.002948051,0.001587766,0.03082182,0.0001728341,0.00004298469,0.000008078887,0.0003141305,0.0006910631,0.9511892,0.00002832816,0.01131986,0.000875851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913943,0.003793492,0.0002356349,0.001353065,0.00003922819,0.0003384502,0.00005384432,0.00002346084,0.002768492],"genre_scores_gemma":[0.9972928,0.0008344433,0.0003536695,0.0003509785,0.0005245543,0.0001189954,0.000074609,0.00005979237,0.0003901776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0332676,"threshold_uncertainty_score":0.8006945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05756154453365862,"score_gpt":0.3402292569346398,"score_spread":0.2826677124009812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}