{"id":"W3048925311","doi":"10.3390/cells9081895","title":"The Hippo Pathway Effector YAP1 Regulates Intestinal Epithelial Cell Differentiation","year":2020,"lang":"en","type":"article","venue":"Cells","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"YAP1; Hippo signaling pathway; Cell biology; Intestinal epithelium; Biology; Stem cell; Cellular differentiation; Gene knockdown; Transcription factor; Wnt signaling pathway; Cell culture; Signal transduction; Epithelium; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008872969,0.0003256348,0.0001979659,0.0002500647,0.0002437124,0.0002561026,0.0001181895,0.0001811759,0.00105265],"category_scores_gemma":[0.00006416161,0.0001212087,0.0001948234,0.0001522098,0.0002442081,0.0002502163,0.0002732062,0.0004196075,0.000238343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002587664,"about_ca_system_score_gemma":0.0002706879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006159082,"about_ca_topic_score_gemma":0.0009760067,"domain_scores_codex":[0.9999347,0.000009724356,0.000004677121,0.00001516391,0.00001707607,0.00001873234],"domain_scores_gemma":[0.9999543,0.000003936858,0.0000166386,0.000002211277,0.000007591165,0.00001520739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005740085,0.000006615791,0.0002413322,0.00004514615,0.000003444925,0.00003767776,0.000009769247,0.00005349761,0.998482,0.00008502111,0.00004280127,0.0009352839],"study_design_scores_gemma":[0.0000154719,0.0001104824,0.02257083,0.00001180761,0.00002096103,0.0001878126,0.00007169414,0.001571159,0.9707845,0.0000915089,0.004556156,0.000007655139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843422,0.007229146,0.005187781,0.0002318134,0.00002925848,0.00003133509,0.0006033754,0.0001236193,0.002221637],"genre_scores_gemma":[0.9934727,0.002387365,0.001220451,0.00004290091,0.000008979398,0.00002488649,0.0004147413,0.00001648426,0.002411499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00105265,"threshold_uncertainty_score":0.003521442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008023730851478486,"score_gpt":0.1940354343981856,"score_spread":0.1860117035467071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}