{"id":"W3048967410","doi":"10.1200/jco.20.01924","title":"PARP Inhibitors in the Management of Ovarian Cancer: ASCO Guideline","year":2020,"lang":"en","type":"review","venue":"Journal of Clinical Oncology","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":310,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"National Institutes of Health","keywords":"Olaparib; Medicine; Oncology; Internal medicine; BRCA mutation; Ovarian cancer; Bevacizumab; Guideline; PARP inhibitor; Cancer; Chemotherapy; Pathology; Poly ADP ribose polymerase; Polymerase; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004526708,0.001411993,0.002319725,0.003222784,0.0008347728,0.001959114,0.004510071,0.006565285,0.005352864],"category_scores_gemma":[0.01158778,0.0007076336,0.003479241,0.003323671,0.0006647063,0.001523337,0.001564408,0.004984334,0.004789166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003244716,"about_ca_system_score_gemma":0.0112602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01714362,"about_ca_topic_score_gemma":0.02360498,"domain_scores_codex":[0.9951041,0.001676783,0.001399198,0.0002563641,0.001281185,0.0002823827],"domain_scores_gemma":[0.9920236,0.001730929,0.00158024,0.0001684872,0.003938159,0.0005585877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009636855,0.00009540937,0.000663951,0.01456359,0.000257669,0.0003150088,0.0001286651,0.00122945,0.0004484703,0.002805691,0.8168834,0.1625124],"study_design_scores_gemma":[0.0003960532,0.0001031168,0.00242748,0.0635811,0.0006620439,0.0007607273,0.00009463316,0.0007148638,0.0002662835,0.005500662,0.9254332,0.0000597165],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002796992,0.5348455,0.01413067,0.3124152,0.02016471,0.005451465,0.02053986,0.0008850467,0.08877055],"genre_scores_gemma":[0.01624451,0.5930502,0.08318898,0.2171267,0.01027122,0.009491411,0.034231,0.0003017515,0.03609424],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01714362,"threshold_uncertainty_score":0.03408772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2527720037666658,"score_gpt":0.5568653200599185,"score_spread":0.3040933162932528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}