{"id":"W3049056316","doi":"10.1016/j.stem.2020.07.015","title":"Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome","year":2020,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":171,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. National Library of Medicine; National Institutes of Health; Cincinnati Children’s Research Foundation; Stanford University; Mayo Clinic","keywords":"Endocardium; Hypoplastic left heart syndrome; Heart development; Biology; Ventricle; Endocardial fibroelastosis; Ascending aorta; Extracellular matrix; Internal medicine; Fibronectin; Cardiology; Heart disease; Cell biology; Aorta; Medicine; Embryonic stem cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000181546,0.0005248294,0.0003030064,0.0006905741,0.0001499635,0.0003764961,0.0003917858,0.000607861,0.002412663],"category_scores_gemma":[0.0007077273,0.0002207473,0.0001560154,0.0002015619,0.0007539281,0.0002967369,0.0004475509,0.0007586114,0.0003297347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001640617,"about_ca_system_score_gemma":0.0001798415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001946362,"about_ca_topic_score_gemma":0.0002195113,"domain_scores_codex":[0.9998775,0.00003014679,0.00001493927,0.00002144245,0.00003483196,0.00002127453],"domain_scores_gemma":[0.9994623,0.0002633965,0.0001146846,0.00004816128,0.00002181905,0.00008963188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005586444,0.00008738413,0.03376086,0.0001402309,0.0000623519,0.0523374,0.000296371,0.001298929,0.8903885,0.006411402,0.0002818149,0.01437626],"study_design_scores_gemma":[0.0003047618,0.0005411611,0.2666262,0.00007902973,0.0003019767,0.200325,0.0005788603,0.01072408,0.5060905,0.007167546,0.007181668,0.0000792951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941669,0.0009711646,0.002208657,0.0001508649,0.00002095885,0.000007968786,0.000118737,0.00005302313,0.002301728],"genre_scores_gemma":[0.9983144,0.0003503168,0.0006272098,0.00003099078,0.00002738301,0.000003750459,0.00006050775,0.00001448592,0.0005709931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002412663,"threshold_uncertainty_score":0.008071184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01174080701862904,"score_gpt":0.2307993382383968,"score_spread":0.2190585312197677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}