{"id":"W3049056316","doi":"10.1016/j.stem.2020.07.015","title":"Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome","year":2020,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":171,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. National Library of Medicine; National Institutes of Health; Cincinnati Children’s Research Foundation; Stanford University; Mayo Clinic","keywords":"Endocardium; Hypoplastic left heart syndrome; Heart development; Biology; Ventricle; Endocardial fibroelastosis; Ascending aorta; Extracellular matrix; Internal medicine; Fibronectin; Cardiology; Heart disease; Cell biology; Aorta; Medicine; Embryonic stem cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001362867,0.0002494,0.0003174372,0.00005625371,0.0001003994,0.00006564485,0.0002740217,0.000157699,0.00008685581],"category_scores_gemma":[0.0000649526,0.0002594347,0.0001993992,0.0001924646,0.00004650301,0.000006091917,0.0004306617,0.0002138035,0.002056116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003321973,"about_ca_system_score_gemma":0.0001481199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009091979,"about_ca_topic_score_gemma":0.00001221531,"domain_scores_codex":[0.9980644,0.0001400894,0.0002366439,0.0006347999,0.0002959858,0.0006281115],"domain_scores_gemma":[0.9987272,0.00006639412,0.00003449274,0.0003969521,0.0001193556,0.0006556064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000174422,0.00005867104,0.00182367,0.000153487,0.00002677686,0.000152758,0.00006989577,0.00009034148,0.987439,0.000003405094,0.009209423,0.0007981666],"study_design_scores_gemma":[0.001091965,0.001672311,0.001607536,0.00001084893,0.00003056467,0.0001015679,0.0000451928,0.00004618111,0.7849842,0.000004137996,0.2100261,0.000379349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924493,0.001461571,0.0004940702,0.000260405,0.0002628947,0.0006890803,0.00006065824,0.00004308241,0.004278977],"genre_scores_gemma":[0.9966874,0.0000366532,0.00008651995,0.0009528729,0.0002849396,0.00002624874,0.00005317359,0.00005223841,0.001819959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2024548,"threshold_uncertainty_score":0.9999858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01174080701862904,"score_gpt":0.2307993382383968,"score_spread":0.2190585312197677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}