{"id":"W3049120799","doi":"10.3389/fimmu.2020.01833","title":"Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H","year":2020,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Cancer Institute; Universitätsklinikum Hamburg-Eppendorf; Medical Research Council; Robert H. Lurie Comprehensive Cancer Center; Hospital for Sick Children; Deutsche Forschungsgemeinschaft; University of Bristol; National Institute for Health and Care Research; Northwestern University","keywords":"Complement system; Factor H; Cell biology; Podocyte; Secretion; Alternative complement pathway; Complement component 3; Biology; Chemistry; Immunology; Kidney; Endocrinology; Antibody; Proteinuria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001173842,0.0003529594,0.0002161278,0.0002719165,0.0001773943,0.0003363098,0.0001038511,0.0003663401,0.001029107],"category_scores_gemma":[0.0001324706,0.0001357774,0.0003576831,0.000222856,0.0001719503,0.0001946828,0.0002397954,0.0003986256,0.0003625014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002509087,"about_ca_system_score_gemma":0.0002939779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001606032,"about_ca_topic_score_gemma":0.001379874,"domain_scores_codex":[0.9998462,0.00001763396,0.0000151093,0.00003021092,0.00005295638,0.00003788724],"domain_scores_gemma":[0.999891,0.00001063224,0.00002237796,0.00002012894,0.00002167573,0.0000340761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003341331,0.000008479332,0.0004443295,0.00002923419,0.00000434823,0.00006092207,0.00001737014,0.00001502954,0.9982016,0.00005522284,0.00002044233,0.001109532],"study_design_scores_gemma":[0.00003318956,0.0002625754,0.03105378,0.00001693515,0.0000402931,0.0007381825,0.00008973161,0.0007078558,0.9613706,0.0001384201,0.005536474,0.00001171074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98403,0.00479582,0.007012499,0.0001400216,0.00003815871,0.00007847539,0.0007478163,0.0001462204,0.003011039],"genre_scores_gemma":[0.9912776,0.001351337,0.003701356,0.0000918334,0.0000136438,0.0000371617,0.0004856882,0.0000134207,0.003027998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001606032,"threshold_uncertainty_score":0.003442705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02695542389068753,"score_gpt":0.2525269626283246,"score_spread":0.2255715387376371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}