{"id":"W3049137390","doi":"10.1093/brain/awaa214","title":"Lack of evidence for genetic association of saposins A, B, C and D with Parkinson’s disease","year":2020,"lang":"en","type":"letter","venue":"Brain","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Center for Advancing Translational Sciences; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; U.S. Department of Health and Human Services; National Institutes of Health; Canada First Research Excellence Fund; Parkinson Canada; National Institute on Aging; Consortium canadien en neurodégénérescence associée au vieillissement; McGill University; Parkinson's Foundation; Brookdale Foundation; Fonds de Recherche du Québec - Santé; Michael J. Fox Foundation for Parkinson's Research","keywords":"Parkinson's disease; Genetic association; Disease; Genetics; Genome-wide association study; Biology; Locus (genetics); Gene; Genotype; Medicine; Internal medicine; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009853466,0.0002659882,0.0005422909,0.0007363376,0.0007477585,0.0004754997,0.0004579395,0.004171446,0.006954414],"category_scores_gemma":[0.008213704,0.0001755172,0.0002576613,0.0005971782,0.0006603235,0.0004176158,0.0001904818,0.001102584,0.001623765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003991965,"about_ca_system_score_gemma":0.0003266039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002251476,"about_ca_topic_score_gemma":0.002481217,"domain_scores_codex":[0.9992735,0.0002340156,0.0001021908,0.0001355115,0.0001879298,0.00006681221],"domain_scores_gemma":[0.9924685,0.005067952,0.0004868209,0.0002621532,0.001255947,0.0004584759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001886124,0.0003251241,0.696834,0.0003106779,0.000238714,0.1075778,0.0006513501,0.0004018133,0.005183701,0.002269199,0.1400012,0.04432033],"study_design_scores_gemma":[0.0006530636,0.00106934,0.603699,0.0005315847,0.0003407805,0.2703334,0.001578026,0.01018924,0.003090322,0.00927542,0.0991033,0.0001364878],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7046638,0.004555442,0.001342098,0.2478622,0.003794682,0.00006064103,0.001319102,0.0001762564,0.03622587],"genre_scores_gemma":[0.9375824,0.001291205,0.0006455115,0.04566595,0.008094656,0.0000284387,0.0003979224,0.00004205678,0.006251896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006954414,"threshold_uncertainty_score":0.02326477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1322749701589277,"score_gpt":0.3676774590201161,"score_spread":0.2354024888611884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}