{"id":"W3049139822","doi":"10.1038/s41467-020-17917-8","title":"Genomic characterization of malignant progression in neoplastic pancreatic cysts","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"PanKind, The Australian Pancreatic Cancer Foundation; Lisa Waller Hayes Foundation; Emerson Collective; National Cancer Institute; National Institutes of Health; Incyte; Rolfe Pancreatic Cancer Foundation; Gerald O. Mann Charitable Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; Sidney Kimmel Foundation for Cancer Research; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation","keywords":"Dysplasia; Pancreatic cancer; Intraductal papillary mucinous neoplasm; Biology; Exome sequencing; Malignant transformation; Pathology; Adenocarcinoma; Cancer; Cancer research; Pancreas; Medicine; Mutation; Gene; Genetics; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001206779,0.00008059949,0.0001369546,0.0006596835,0.0001495197,0.0002957771,0.0001082797,0.0001565729,0.0008451529],"category_scores_gemma":[0.0006478251,0.00007810172,0.0001347642,0.0005201646,0.000134394,0.0001392391,0.0001915127,0.0001604141,0.0001397953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001122176,"about_ca_system_score_gemma":0.00009171167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005342654,"about_ca_topic_score_gemma":0.00111198,"domain_scores_codex":[0.9999012,0.00001384601,0.000007475664,0.00003455229,0.00002556959,0.00001725026],"domain_scores_gemma":[0.9997213,0.0001140824,0.00007753345,0.00002644873,0.00003545747,0.00002500514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004565873,0.00004230691,0.5686029,0.0001301701,0.0001555883,0.001600297,0.0005642342,0.001106122,0.3819054,0.0003592058,0.0003510513,0.04472606],"study_design_scores_gemma":[0.000005050224,0.00008052964,0.9749686,0.000009033823,0.0000574029,0.002779478,0.000222063,0.001251315,0.0182464,0.0002432669,0.002131459,0.000005372973],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981699,0.0002936098,0.0006503694,0.00002213551,0.00000162535,0.000003501922,0.0004130525,0.00001000338,0.000435755],"genre_scores_gemma":[0.9973685,0.0002441506,0.0009102137,0.00002322349,0.000004427675,0.000009713033,0.001095269,0.00001099779,0.0003334541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008451529,"threshold_uncertainty_score":0.002827346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03846660602052903,"score_gpt":0.3635932422083381,"score_spread":0.3251266361878091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}