{"id":"W3049139822","doi":"10.1038/s41467-020-17917-8","title":"Genomic characterization of malignant progression in neoplastic pancreatic cysts","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"PanKind, The Australian Pancreatic Cancer Foundation; Lisa Waller Hayes Foundation; Emerson Collective; National Cancer Institute; National Institutes of Health; Incyte; Rolfe Pancreatic Cancer Foundation; Gerald O. Mann Charitable Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; Sidney Kimmel Foundation for Cancer Research; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation","keywords":"Dysplasia; Pancreatic cancer; Intraductal papillary mucinous neoplasm; Biology; Exome sequencing; Malignant transformation; Pathology; Adenocarcinoma; Cancer; Cancer research; Pancreas; Medicine; Mutation; Gene; Genetics; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001743895,0.00008393192,0.0003399276,0.0001047637,0.00005614524,0.000005210181,0.0003088548,0.0002049542,0.00004764564],"category_scores_gemma":[0.0004669481,0.00006943149,0.00004112896,0.0004003049,0.0001256208,0.0000439105,0.0001661451,0.0006089247,0.000027055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005945066,"about_ca_system_score_gemma":0.00022696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009266514,"about_ca_topic_score_gemma":0.00002310538,"domain_scores_codex":[0.9990948,0.0001423896,0.0003149862,0.0001379531,0.0001662451,0.0001436588],"domain_scores_gemma":[0.9988079,0.0002234544,0.0001152798,0.0006277842,0.0001204575,0.0001051427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001823118,0.0002548119,0.7340562,0.0001296436,0.00004010852,0.000008810392,0.0008134461,6.979559e-7,0.2613012,0.00136125,0.0001053476,0.001746166],"study_design_scores_gemma":[0.0009061999,0.000242102,0.9887577,0.0002517507,0.00009326465,0.00001661369,0.00007852356,0.006299815,0.00112958,0.00002953827,0.002128604,0.00006630941],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848351,0.001364695,0.0001394405,0.01103788,0.00002467455,0.0006187532,0.00001623419,0.00002938134,0.001933843],"genre_scores_gemma":[0.9939349,0.001167864,0.004037182,0.000461737,0.00003404153,0.00006462626,0.0002295826,0.00001264716,0.00005742495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2601716,"threshold_uncertainty_score":0.2831334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03846660602052903,"score_gpt":0.3635932422083381,"score_spread":0.3251266361878091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}