{"id":"W3049148848","doi":"10.1002/adtp.202000123","title":"Nanoparticles Loaded with Wnt and YAP/Mevalonate Inhibitors in Combination with Paclitaxel Stop the Growth of TNBC Patient‐Derived Xenografts and Diminish Tumorigenesis","year":2020,"lang":"en","type":"article","venue":"Advanced Therapeutics","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Children's Hospital of Eastern Ontario; Health Canada; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Paclitaxel; Triple-negative breast cancer; Wnt signaling pathway; Cancer research; Breast cancer; Medicine; Carcinogenesis; Chemotherapy; Cancer stem cell; Cancer; Oncology; Pharmacology; Internal medicine; Chemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007123035,0.0001514347,0.0001570775,0.00002251312,0.00006808562,0.00001585229,0.00007236118,0.00005417111,7.003925e-7],"category_scores_gemma":[0.00001446285,0.00010019,0.00001856172,0.0001503638,0.000201224,0.000009822399,0.00003805275,0.0000765807,2.176502e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005279916,"about_ca_system_score_gemma":0.00003520282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001216263,"about_ca_topic_score_gemma":0.00002539877,"domain_scores_codex":[0.9991891,0.00007536553,0.0001822057,0.0002534594,0.0001326993,0.000167213],"domain_scores_gemma":[0.9995797,0.00003175965,0.0001120861,0.0001255501,0.00009174574,0.00005920123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004048542,0.00005951282,0.006383397,0.00002982722,0.00004510246,0.000004609212,0.001895526,0.00008110581,0.9818642,0.00007259957,3.435067e-7,0.009158937],"study_design_scores_gemma":[0.001474132,0.001999065,0.004921864,0.00003859327,0.00003560579,0.000006083058,0.001390921,0.00006807121,0.9893309,0.000138002,0.0004298976,0.0001668026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973611,0.001555887,0.0002088728,0.000572955,0.00002139268,0.0002451609,0.00001044679,0.00001113702,0.00001309599],"genre_scores_gemma":[0.9986294,0.0003065538,0.0005412858,0.0004445377,0.00001749528,0.00002066846,0.00001400996,0.00002225325,0.000003782621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008992135,"threshold_uncertainty_score":0.408563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01131716316574512,"score_gpt":0.214005417259994,"score_spread":0.2026882540942489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}