{"id":"W3049150590","doi":"10.1161/circgen.119.002769","title":"Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus","year":2020,"lang":"en","type":"article","venue":"Circulation Genomic and Precision Medicine","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Helmholtz Zentrum München; Amity Institute of Biotechnology, Amity University; School of Medicine, Stanford University; Terveyden ja hyvinvoinnin laitos; Karl-Franzens-Universität Graz; Medical Research Council; Tartu Ülikool; Uppsala Universitet; Sydäntutkimussäätiö; Stockholms Läns Landsting; British Heart Foundation; Háskóli Íslands; Kuopion Yliopistollinen Sairaala; National Institute of Diabetes and Digestive and Kidney Diseases; Helsingin ja Uudenmaan Sairaanhoitopiiri; Knut och Alice Wallenbergs Stiftelse; King Abdulaziz University; Karolinska Institutet; Yrjö Jahnssonin Säätiö; Fudan University; Lunds Universitet; Eesti Teadusagentuur; Perelman School of Medicine, University of Pennsylvania; Amity University; Juho Vainion Säätiö; American Heart Association; Broad Institute; Deutsches Zentrum für Herz-Kreislaufforschung; Stanford Diabetes Research Center; Oxford University Hospitals NHS Foundation Trust; Vetenskapsrådet; Tulane University; Torsten Söderbergs Stiftelse; Genomic Health; Foundation for Cardiovascular Research; National Heart, Lung, and Blood Institute; Itä-Suomen Yliopisto; Brigham and Women's Hospital; University of Leicester; Cleveland Clinic; Institute of Genetics; Hjärt-Lungfonden; Medizinische Universität Graz; University of Pennsylvania; Science for Life Laboratory; Queen Mary University of London; National Institute for Health and Care Research; Massachusetts General Hospital; Wellcome Trust; University of Southern California; Stanford Cardiovascular Institute, School of Medicine, Stanford University; AstraZeneca; European Commission; Helsingin Yliopisto; Erasmus Medisch Centrum; Stiftelsen för Strategisk Forskning; University of Oxford; University of Dundee","keywords":"Coronary artery disease; CAD; Type 2 diabetes; Internal medicine; Diabetes mellitus; Medicine; Genetic testing; Genetic association; Genetic predisposition; Disease; Genetics; Biology; Single-nucleotide polymorphism; Endocrinology; Genotype; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001978057,0.0001057725,0.0001657845,0.00005063547,0.00004606411,0.000005437903,0.00007118161,0.00008261501,0.00006095207],"category_scores_gemma":[0.0003206386,0.00009760297,0.00002266526,0.0001152721,0.00003916477,0.000002981959,0.00005509248,0.00005168188,0.00002072263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001679699,"about_ca_system_score_gemma":0.00003246268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004647181,"about_ca_topic_score_gemma":0.000003271382,"domain_scores_codex":[0.9990432,0.0001035429,0.0002862751,0.0003313147,0.00008210563,0.000153543],"domain_scores_gemma":[0.9994676,0.00004111836,0.00005954639,0.0001481498,0.00004888731,0.0002346589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001870602,0.00001854846,0.8302296,0.00001929273,0.0000217423,0.000003760143,0.000356221,0.00952582,0.1285527,0.00001560777,0.002130835,0.02893879],"study_design_scores_gemma":[0.0004675473,0.0002525022,0.9889571,0.00002009133,0.00002051458,0.000001850188,0.00003676823,0.006326475,0.0000420999,0.0003577202,0.003412852,0.0001044979],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859796,0.005078642,0.005764042,0.002669957,0.0001483422,0.0002794614,0.000008801057,0.000007711207,0.00006351536],"genre_scores_gemma":[0.9955505,0.0007591161,0.0007008677,0.00242755,0.0003462681,0.00001435543,0.000165278,0.00001168841,0.00002444759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1587274,"threshold_uncertainty_score":0.3980134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01616450425525911,"score_gpt":0.2529964434819196,"score_spread":0.2368319392266605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}