{"id":"W3049150590","doi":"10.1161/circgen.119.002769","title":"Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus","year":2020,"lang":"en","type":"article","venue":"Circulation Genomic and Precision Medicine","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Helmholtz Zentrum München; Amity Institute of Biotechnology, Amity University; School of Medicine, Stanford University; Terveyden ja hyvinvoinnin laitos; Karl-Franzens-Universität Graz; Medical Research Council; Tartu Ülikool; Uppsala Universitet; Sydäntutkimussäätiö; Stockholms Läns Landsting; British Heart Foundation; Háskóli Íslands; Kuopion Yliopistollinen Sairaala; National Institute of Diabetes and Digestive and Kidney Diseases; Helsingin ja Uudenmaan Sairaanhoitopiiri; Knut och Alice Wallenbergs Stiftelse; King Abdulaziz University; Karolinska Institutet; Yrjö Jahnssonin Säätiö; Fudan University; Lunds Universitet; Eesti Teadusagentuur; Perelman School of Medicine, University of Pennsylvania; Amity University; Juho Vainion Säätiö; American Heart Association; Broad Institute; Deutsches Zentrum für Herz-Kreislaufforschung; Stanford Diabetes Research Center; Oxford University Hospitals NHS Foundation Trust; Vetenskapsrådet; Tulane University; Torsten Söderbergs Stiftelse; Genomic Health; Foundation for Cardiovascular Research; National Heart, Lung, and Blood Institute; Itä-Suomen Yliopisto; Brigham and Women's Hospital; University of Leicester; Cleveland Clinic; Institute of Genetics; Hjärt-Lungfonden; Medizinische Universität Graz; University of Pennsylvania; Science for Life Laboratory; Queen Mary University of London; National Institute for Health and Care Research; Massachusetts General Hospital; Wellcome Trust; University of Southern California; Stanford Cardiovascular Institute, School of Medicine, Stanford University; AstraZeneca; European Commission; Helsingin Yliopisto; Erasmus Medisch Centrum; Stiftelsen för Strategisk Forskning; University of Oxford; University of Dundee","keywords":"Coronary artery disease; CAD; Type 2 diabetes; Internal medicine; Diabetes mellitus; Medicine; Genetic testing; Genetic association; Genetic predisposition; Disease; Genetics; Biology; Single-nucleotide polymorphism; Endocrinology; Genotype; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009514359,0.0003802655,0.0004864508,0.001278295,0.000635743,0.0005104508,0.0003155139,0.0005692301,0.002304056],"category_scores_gemma":[0.002521638,0.0002430708,0.0006750739,0.002172469,0.000437405,0.0002021319,0.0005388709,0.00059515,0.0001890468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001705627,"about_ca_system_score_gemma":0.0003332619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003146874,"about_ca_topic_score_gemma":0.002878297,"domain_scores_codex":[0.9993411,0.0002498804,0.00006650325,0.00017626,0.0001005547,0.00006573989],"domain_scores_gemma":[0.9987545,0.0004152555,0.0004213129,0.0001350579,0.00008693861,0.0001869148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001760998,0.00001859991,0.9964238,0.00001916649,0.0001724599,0.0002868951,0.00004418201,0.00005956838,0.0006847424,0.00003735587,0.00004579478,0.002031281],"study_design_scores_gemma":[0.00001064958,0.0000672082,0.9983071,0.00001523636,0.0001620089,0.0008828678,0.00005418546,0.0001031808,0.0001105143,0.00009458669,0.0001890523,0.000003407598],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973547,0.0009945426,0.0005021826,0.00007246594,0.00001560567,0.00001851403,0.0002529245,0.00000627283,0.0007828516],"genre_scores_gemma":[0.9986651,0.0004749919,0.0004233799,0.00003823036,0.00003883848,0.00001194381,0.0002197774,0.000002735758,0.0001250753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003146874,"threshold_uncertainty_score":0.007707834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01616450425525911,"score_gpt":0.2529964434819196,"score_spread":0.2368319392266605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}