{"id":"W3049182325","doi":"10.1158/1078-0432.ccr-20-2429","title":"Moving Beyond BRCA—Incorporating Molecular Assays into Ovarian Cancer Trials","year":2020,"lang":"en","type":"letter","venue":"Clinical Cancer Research","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"Government of Ontario; Ontario Institute for Cancer Research","keywords":"Ovarian cancer; Oncology; Medicine; Prospective cohort study; Clinical trial; Internal medicine; Cancer; Serous fluid; Gynecology; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03566552,0.0005700258,0.001761484,0.0007685745,0.0009835445,0.004253745,0.001952308,0.01587383,0.004006535],"category_scores_gemma":[0.06829069,0.0005649506,0.001408394,0.0009375303,0.002991993,0.005574292,0.002264513,0.0149869,0.003128048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003715886,"about_ca_system_score_gemma":0.00433317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001100518,"about_ca_topic_score_gemma":0.002309796,"domain_scores_codex":[0.9746546,0.01915847,0.001607694,0.00113797,0.002645584,0.0007956991],"domain_scores_gemma":[0.9213793,0.06061993,0.00319418,0.002531742,0.005099094,0.007175784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008719425,0.0007848717,0.01226453,0.0008343175,0.0004252946,0.002437968,0.0003300809,0.002038261,0.006151148,0.02785612,0.4691554,0.4690026],"study_design_scores_gemma":[0.01175066,0.005357872,0.01625425,0.002842131,0.0005279403,0.002893473,0.0003557052,0.008019669,0.005078619,0.1574174,0.7892205,0.000281726],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.004901641,0.009320353,0.001734861,0.9665335,0.01100094,0.0002525696,0.0002569032,0.0001062502,0.005892957],"genre_scores_gemma":[0.04158692,0.004485529,0.005915009,0.9122937,0.03277358,0.0006609568,0.0001607201,0.0000598658,0.0020638],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03566552,"threshold_uncertainty_score":0.1886196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2014871628831764,"score_gpt":0.5089592626528809,"score_spread":0.3074720997697046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}