{"id":"W3049239269","doi":"10.1158/1078-0432.ccr-20-1439","title":"A Preclinical Trial and Molecularly Annotated Patient Cohort Identify Predictive Biomarkers in Homologous Recombination–deficient Pancreatic Cancer","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Queen's University; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Occupational Cancer Research Centre; Princess Margaret Cancer Centre; McGill University; McGill Genome Centre; Ontario Institute for Cancer Research; McGill University and Génome Québec Innovation Centre; McGill University Health Centre","funders":"Canadian Cancer Society Research Institute; Cancer Research Society; McGill University Health Centre; Terry Fox Research Institute; Ontario Institute for Cancer Research; Princess Margaret Cancer Foundation","keywords":"Transcriptome; Pancreatic cancer; Homologous recombination; PARP inhibitor; Cancer research; Biology; Genome instability; Cancer; Medicine; Oncology; Internal medicine; Gene; Genetics; Poly ADP ribose polymerase; DNA damage; Gene expression; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002917346,0.0006263079,0.0008209629,0.0002507061,0.0003092062,0.0006739701,0.0004437566,0.0007128515,0.002085027],"category_scores_gemma":[0.0009986821,0.0002351627,0.0006433345,0.0002888536,0.0005588228,0.0005335138,0.0004029707,0.001114901,0.0005567998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005322929,"about_ca_system_score_gemma":0.0008489734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001893563,"about_ca_topic_score_gemma":0.0002871222,"domain_scores_codex":[0.9993685,0.0003043705,0.00004419404,0.0001271569,0.00008584436,0.00006992221],"domain_scores_gemma":[0.9990672,0.0001568354,0.0001983253,0.0002264415,0.0000902137,0.0002610664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.351908,0.03819358,0.2349255,0.00065826,0.001834247,0.0008255143,0.000254933,0.006919967,0.2860765,0.000920846,0.00348424,0.07399843],"study_design_scores_gemma":[0.06829831,0.5253224,0.2621498,0.00008565185,0.002795263,0.00285191,0.0002530798,0.01306217,0.1117896,0.001471844,0.01183427,0.00008581823],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967224,0.0004896064,0.0008823453,0.00009597129,0.00002133449,0.0004565366,0.000712348,0.00002348166,0.0005960133],"genre_scores_gemma":[0.9941785,0.0002124286,0.001245306,0.0001835727,0.00003323167,0.0007110864,0.002803163,0.00001346348,0.0006191908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002917346,"threshold_uncertainty_score":0.0154286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2549166930190127,"score_gpt":0.5434493464092846,"score_spread":0.2885326533902718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}