{"id":"W3049276429","doi":"10.1016/j.ebiom.2020.102946","title":"Is loss of perineuronal nets a critical pathological event in Alzheimer's disease?","year":2020,"lang":"en","type":"letter","venue":"EBioMedicine","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Tauopathy; Disease; Dementia; Pathological; Pathogenesis; Neuroscience; Medicine; Alzheimer's disease; Amyloid (mycology); Pathology; Bioinformatics; Neurodegeneration; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001622021,0.0003646526,0.0008737735,0.0004052403,0.001604026,0.001609065,0.0007917043,0.0252446,0.003544851],"category_scores_gemma":[0.009754123,0.0002793816,0.0005786557,0.0003762867,0.002187741,0.002491568,0.000793922,0.01552309,0.003712052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002344934,"about_ca_system_score_gemma":0.001908632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002495877,"about_ca_topic_score_gemma":0.003757753,"domain_scores_codex":[0.999238,0.000236331,0.0001051594,0.0000858885,0.0002326271,0.0001019162],"domain_scores_gemma":[0.9967734,0.001712982,0.0003063398,0.0001439673,0.000605549,0.0004577934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003261737,0.0001021558,0.00249587,0.0002138748,0.00002980173,0.01408139,0.000175092,0.00008401567,0.001198205,0.007003978,0.9125316,0.06175777],"study_design_scores_gemma":[0.0003555153,0.000274177,0.004154045,0.0006751193,0.00004818553,0.01938931,0.0006241169,0.0005145578,0.0006315801,0.02817445,0.9450895,0.000069469],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001196256,0.007625516,0.000122138,0.9753161,0.01223164,0.000009065433,0.00002838683,0.00002506972,0.003445786],"genre_scores_gemma":[0.01709587,0.01267493,0.0004676721,0.8614324,0.1002372,0.00003848179,0.00004497956,0.00001614042,0.007992405],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.0252446,"threshold_uncertainty_score":0.01701379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05501621419098419,"score_gpt":0.3633043928031336,"score_spread":0.3082881786121495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}